Actigraphic sleep duration and fragmentation in older women: Associations with performance across cognitive domains

Adam P. Spira, Katie L. Stone, Susan Redline, Kristine E. Ensrud, Sonia Ancoli-Israel, Jane A. Cauley, Kristine Yaffe

Research output: Contribution to journalArticlepeer-review

Abstract

Study Objectives: To determine the association of actigraphic sleep duration and fragmentation with cognition in community-dwelling older women. Methods: We studied 782 women (mean age = 87.4) of varied cognitive status from the Study of Osteoporotic Fractures who completed wrist actigraphy and the Modified Mini-Mental State Examination (3MS), California Verbal Learning Test-II-Short Form, digit span, verbal fluency tests, and the Trailmaking Test, Part B (Trails B). Total sleep time (TST) and wake after sleep onset (WASO) tertiles were our primary predictors. Results: There were few significant associations in adjusted analyses. Compared to women with intermediate TST (mean = 430.1 minutes), those with the longest (508.7 minutes) had significantly poorer performance on the 3MS and phonemic and semantic fluency. Compared to women with the least WASO (31.5 minutes), those in the middle tertile (61.5 minutes) had significantly poorer delayed recall and those in the middle tertile and highest tertile (126.2 minutes) had poorer total recall and semantic fluency. We observed significant adjusted associations of TST with impaired 3MS performance and of WASO with impaired delayed recall, semantic fluency, and digit span. After excluding participants with adjudicated dementia diagnoses or indeterminate cognitive status, some adjusted associations remained but decreased in magnitude, others became nonsignificant, and a new association emerged. Conclusions: In community-dwelling older women, longer objectively measured sleep duration and greater sleep fragmentation are associated with poorer performance and impairment in only a subset of cognitive domains. Some of these associations may be driven by women with dementia in whom disturbed sleep and cognitive performance share an underlying neuropathological basis.

Original languageEnglish (US)
Article numberzsx073
JournalSleep
Volume40
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • Actigraphy
  • Cognition
  • Impairment
  • Neuropsychological
  • Older adults

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

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