ACTH-cortisol activity during the 17β-estradiol and LH preovulatory surges of the menstrual cycle in the human

Bernard Kerdelhue, Véronique Lenoir, Robert Scholler, Howard Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: A strong positive coupling has been already documented between the adrenocortical axis and the gonadal axis at the time of the initiation of the preovulatory LH surge of the menstrual cycle in the human. The LH preovulatory surge starts in the morning at the time of the acrophase (maximal plasma cortisol values) of the cortisol circadian rhythm. Also, it was shown that morning maximal plasma cortisol values were higher during the follicular phase than during the luteal phase. The objective of the present study was designed to determine the exact day of the fall of morning maximal plasma cortisol values and the functional correlates which could exist between plasma 17β-Estradiol, LH, ACTH and Cortisol at the time of the preovulatory LH surge. Methods: We performed a detailed analysis of variations of plasma ACTH and cortisol concentrations during the various phases of the LH surge: 1) the day before the ascending phase, 2) the day of the ascending phase, 3) the day of the LH peak, 4) the day of the descending phase, 5) the day after the descending phase. 17P-Estradiol, LH and FSH were determined by microparticle enzyme immunoassays kits and Progesterone determination was made using a radioimmunoassay kit. ACTH determination was made using a RIA kit and Cortisol was assayed by a RIA method. Results: Plasma ACTH concentrations were at their highest the day before the day of the ascending phase of the LH surge and significantly higher than the day of the descending phase and the day after the day of the descending phase (p<0.02). Plasma cortisol concentrations were at their highest, with almost similar values, the day before the day of the ascending phase, the day of the ascending phase and the day of the LH peak; then, plasma cortisol concentrations were significantly lower than those of the preceding days, the day of the descending phase (p=0.0001) and the day after the day of the descending phase (p=0.02), when plasma 17β-Estradiol starts to decrease. Conclusion: Overall, these results suggest that the positive ACTH-Cortisol-Estrogen dependency, well documented in the female rat, is also operating at midcycle during the menstrual cycle in the human.

Original languageEnglish (US)
Pages (from-to)114-120
Number of pages7
JournalNeuroendocrinology Letters
Volume27
Issue number1-2
StatePublished - Feb 2006

Keywords

  • ACTH
  • Cortisol
  • E2 and LH preovulatory surges
  • Human
  • Menstrual cycle

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'ACTH-cortisol activity during the 17β-estradiol and LH preovulatory surges of the menstrual cycle in the human'. Together they form a unique fingerprint.

Cite this