ACTH, β-endorphin, substance P, and corticotrophin releasing hormone in plasma and follicular fluid in hormonally stimulated menstrual cycles for in-vitro fertilization in the human

Bernard Kerdelhué, Véronique Lenoir, Paul Kolm, Howard J. Seltman, Howard W. Jones, Georgeanna Seegar Jones

Research output: Contribution to journalArticle

Abstract

Changes in plasma concentrations of ACTH, β-endorphin (β-EP) and cortisol have been found to be associated during the human menstrual cycle. Changes in hypothalamic levels of gonadotrophin releasing hormone (GnRH), β-EP and substance P (SP) have also been associated with the oestrous cycle in the rat. Therefore, an attempt was made to measure the activity of the corticotrophic axis and SP by measuring blood and follicular fluid concentrations of ACTH, β-EP, SP and corticotrophin releasing hormone (CRH) during the hormonal ovarian stimulation phase for in-vitro fertilization (IVF), in a series of 19 patients. At the plasma level, there was no significant change over treatment days in ACTH (P = 0.1550), β-EP (P = 0.1137), or SP concentrations (P = 0.5625). CRH was not detectable over treatment days. In addition, there was no significant change in neuropeptide over treatment days between those women who became pregnant and those who did not (P = 0.17 for all). In the follicular fluid, ACTH was not detectable, β-EP concentration was three times higher than in the plasma, CRH was detectable, and SP concentration was similar to that of plasma. There was no apparent correlation, however, between β-EP or SP concentrations in the plasma and follicular fluid from a given patient. In conclusion, the absence of changes in the activity of the corticotrophic axis' during the hormonal ovarian stimulation suggests that there was no major stress component associated,with the stimulation phase of IVF or the occurrence of a pregnancy.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalHuman Reproduction
Volume12
Issue number2
DOIs
StatePublished - Feb 1997

Keywords

  • ACTH
  • CRH
  • IVF
  • SP
  • β-endorphin

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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