Acrylamide polymerization: New method for determining the oxygen content in blood

Judah Folkman; Howard Conn; Richard Harmel

doi:10.1126/science.178.4057.170

Acrylamide polymerization: New method for determining the oxygen content in blood

Judah Folkman, Howard Conn, Richard Harmel

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A new principle for determining the oxygen content of 0.1-milliliter blood samples has been developed, based on measurement of the delay in gelation during copolymerization of acrylamide and bisacrylamide initiated by free radicals. The logarithm of this time interval is linearly proportional to the oxygen content of the blood sample over the range 0 to 22 milliliters of oxygen per 100 milliliters of whole blood. Physiological variations of pH and pCO₂ do not affect the sensitivity of the assay.

Original language	English (US)
Pages (from-to)	170-172
Number of pages	3
Journal	Science
Volume	178
Issue number	4057
DOIs	https://doi.org/10.1126/science.178.4057.170
State	Published - Jan 1 1972

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abstract = "A new principle for determining the oxygen content of 0.1-milliliter blood samples has been developed, based on measurement of the delay in gelation during copolymerization of acrylamide and bisacrylamide initiated by free radicals. The logarithm of this time interval is linearly proportional to the oxygen content of the blood sample over the range 0 to 22 milliliters of oxygen per 100 milliliters of whole blood. Physiological variations of pH and pCO2 do not affect the sensitivity of the assay.",

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Acrylamide polymerization: New method for determining the oxygen content in blood

Abstract

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