TY - JOUR
T1 - Acquired von Willebrand disease and multiple myeloma
T2 - A case report of a breast cancer survivor
AU - Jin, Ning
AU - Salahuddin, Farah F.
AU - Nesbitt, John A.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Acquired von Willebrand disease (aVWD) is rare disease and is associated with a variety of underlying diseases. We report a case of aVWD in the setting of multiple myeloma. The patient was a 63-year-old female with breast cancer in remission who was admitted for symptomatic anemia. She was diagnosed with multiple myeloma. She also had subcutaneous bleeding before admission. Laboratory studies revealed isolated prolongation of the activated partial thromboplastin time, which corrected in a mixing study. Her factor VIII activity, von Willebrand factor (VWF) Ag, and VWF activity were low. VWF multimer study confirmed the patient had aVWD. The treatment of aVWD is discussed in this article, including the treatment of underlying diseases, and acute management in emergent situations. An intriguing question in this case is whether the patient's multiple myeloma is a chemotherapy-induced hematological malignancy or a second primary malignancy.
AB - Acquired von Willebrand disease (aVWD) is rare disease and is associated with a variety of underlying diseases. We report a case of aVWD in the setting of multiple myeloma. The patient was a 63-year-old female with breast cancer in remission who was admitted for symptomatic anemia. She was diagnosed with multiple myeloma. She also had subcutaneous bleeding before admission. Laboratory studies revealed isolated prolongation of the activated partial thromboplastin time, which corrected in a mixing study. Her factor VIII activity, von Willebrand factor (VWF) Ag, and VWF activity were low. VWF multimer study confirmed the patient had aVWD. The treatment of aVWD is discussed in this article, including the treatment of underlying diseases, and acute management in emergent situations. An intriguing question in this case is whether the patient's multiple myeloma is a chemotherapy-induced hematological malignancy or a second primary malignancy.
KW - Acquired von Willebrand disease
KW - Breast cancer
KW - Chemotherapy
KW - Multiple myeloma
UR - http://www.scopus.com/inward/record.url?scp=84927695891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927695891&partnerID=8YFLogxK
U2 - 10.1097/MBC.0000000000000149
DO - 10.1097/MBC.0000000000000149
M3 - Article
C2 - 24911454
AN - SCOPUS:84927695891
VL - 25
SP - 890
EP - 893
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
SN - 0957-5235
IS - 8
ER -