TY - JOUR
T1 - Acquired toxoplasmic retinitis in an immunosuppressed patient
T2 - Diagnosis by transvitreal fine-needle aspiration biopsy
AU - Palkovacs, Elizabeth M.
AU - Correa, Zelia
AU - Augsburger, James J.
AU - Eagle, Ralph C.
N1 - Funding Information:
Support: This work was supported in part by a Departmental Challenge grant from Research to Prevent Blindness, Inc., New York, New York, to the Department of Ophthalmology, University of Cincinnati College of Medicine (James J. Augsburger, Chairman), and the Research and Education Fund of the Department of Ophthalmology, University of Cincinnati College of Medicine. E.M.Palkovacs.Z.Correa(*).J.J.Augsburger Department of Ophthalmology, University of Cincinnati College of Medicine, 260 Stetson Street, Suite 5300, P.O. Box 670527, Cincinnati, OH 45267–0527, USA e-mail: correazm@uc.edu
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - Background: Acquired multifocal white retinal lesions in an immunosuppressed patient are diagnostically challenging. Methods: Case report of a 34-year-old woman who underwent bone marrow transplantation for chronic myelogenous leukemia. Four months after the transplant, while on relatively high doses of immunosuppressive drugs, she developed bilateral multifocal retinitis versus leukemic retinal infiltration. Fine-needle aspiration biopsy was performed on one eye in an attempt to establish a cytological diagnosis. Results: The aspirate was found to contain individual crescent-shaped intraretinal organisms and cysts, consistent with the diagnosis of toxoplasmic retinitis. The patient was started immediately on an anti-toxoplasmosis regimen consisting of sulfadiazine, pyrimethamine, and folinic acid. Follow-up examinations revealed complete inactivation of the retinitis and no delayed complications of the biopsy. Conclusion: Fine-needle aspiration biopsy can be a useful diagnostic tool in selected patients with acquired retinal infiltrates.
AB - Background: Acquired multifocal white retinal lesions in an immunosuppressed patient are diagnostically challenging. Methods: Case report of a 34-year-old woman who underwent bone marrow transplantation for chronic myelogenous leukemia. Four months after the transplant, while on relatively high doses of immunosuppressive drugs, she developed bilateral multifocal retinitis versus leukemic retinal infiltration. Fine-needle aspiration biopsy was performed on one eye in an attempt to establish a cytological diagnosis. Results: The aspirate was found to contain individual crescent-shaped intraretinal organisms and cysts, consistent with the diagnosis of toxoplasmic retinitis. The patient was started immediately on an anti-toxoplasmosis regimen consisting of sulfadiazine, pyrimethamine, and folinic acid. Follow-up examinations revealed complete inactivation of the retinitis and no delayed complications of the biopsy. Conclusion: Fine-needle aspiration biopsy can be a useful diagnostic tool in selected patients with acquired retinal infiltrates.
KW - Fine needle aspiration biopsy
KW - Immunosupression
KW - Leukemia
KW - Retinal infiltrates
KW - Toxoplasmosis
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U2 - 10.1007/s00417-008-0838-z
DO - 10.1007/s00417-008-0838-z
M3 - Article
C2 - 18500530
AN - SCOPUS:51649099953
SN - 0721-832X
VL - 246
SP - 1495
EP - 1497
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 10
ER -