TY - JOUR
T1 - Acquired resistance in mycobacterium avium complex strains isolated from AIDS patients and beige mice daring treatment with clarithromycin
AU - Doucet-populaire, Florence
AU - Truffot-pernot, Chantal
AU - Grosset, Jacques
AU - Jarlier, Vincent
N1 - Funding Information:
F. D.-P. thanks Hiroshi Nikaido in whose laboratory part of this work was carried out for encouragement and hospitality. We thank Robert C. Goldman, Abbott Laboratories, for his interest in our work and for sharing his knowledge with us. This study was supported by the Agence Nationale de Recherches sur le Sida (A.N.R.S.). F. D.-P. was the recipient of a fellowship from the Agence Nationale de Recherches sur le Sida (A.N.R.S.).
PY - 1995/7
Y1 - 1995/7
N2 - Clarithromycin has been reported to select clarithromycin resistant mutants of Mycobacterium avium complex (MAC) during treatment with clarithromycin in AIDS patients and beige mice. We selected resistant mutants in vitro at a frequency of 5 × 10-9. Clarithromycin resistant strains of MAC isolated in AIDSpatients and beige mice as well as derivatives selected in vitro had a unique pattern of acquired cross-resistance to macrolides and related antibiotics. In contrast, the pattern of resistance to non-macrolide antibiotics remained unchanged in clarithromycin resistant strains. A dramatic decrease in ribosome affinity for clarithromycin and erythromycin was found in clarithromycin resistant strains, but no mutation was found in the peptidyl domain of the 23S rRNA, indicating that another ribosomal modification is involved.
AB - Clarithromycin has been reported to select clarithromycin resistant mutants of Mycobacterium avium complex (MAC) during treatment with clarithromycin in AIDS patients and beige mice. We selected resistant mutants in vitro at a frequency of 5 × 10-9. Clarithromycin resistant strains of MAC isolated in AIDSpatients and beige mice as well as derivatives selected in vitro had a unique pattern of acquired cross-resistance to macrolides and related antibiotics. In contrast, the pattern of resistance to non-macrolide antibiotics remained unchanged in clarithromycin resistant strains. A dramatic decrease in ribosome affinity for clarithromycin and erythromycin was found in clarithromycin resistant strains, but no mutation was found in the peptidyl domain of the 23S rRNA, indicating that another ribosomal modification is involved.
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U2 - 10.1093/jac/36.1.129
DO - 10.1093/jac/36.1.129
M3 - Article
C2 - 8537260
AN - SCOPUS:0029157406
SN - 0305-7453
VL - 36
SP - 129
EP - 136
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 1
ER -