Acquired immunodeficiency syndrome in the child of a haemophiliac

Margaret V. Ragni, Sharon Kiernan, Bernard Cohen, Alan Winkelstein, Basil Z. Zitelli, Franklin A. Bontempo, Andrew H. Urbach, Joseph Stambouli, Bruce S. Rabin, J. Carlton Gartner, J. Jeffrey Malatack, Joel A. Spero, Jessica H. Lewis

Research output: Contribution to journalLetter

Abstract

Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.

Original languageEnglish (US)
Pages (from-to)133-135
Number of pages3
JournalLancet
Volume1
Issue number8421
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Ragni, M. V., Kiernan, S., Cohen, B., Winkelstein, A., Zitelli, B. Z., Bontempo, F. A., Urbach, A. H., Stambouli, J., Rabin, B. S., Gartner, J. C., Malatack, J. J., Spero, J. A., & Lewis, J. H. (1985). Acquired immunodeficiency syndrome in the child of a haemophiliac. Lancet, 1(8421), 133-135. https://doi.org/10.1016/S0140-6736(85)91011-6