Acquired immunodeficiency syndrome in the child of a haemophiliac

Margaret V. Ragni; Sharon Kiernan; Bernard Cohen; Alan Winkelstein; Basil Z. Zitelli; Franklin A. Bontempo; Andrew H. Urbach; Joseph Stambouli; Bruce S. Rabin; J. Carlton Gartner; J. Jeffrey Malatack; Joel A. Spero; Jessica H. Lewis

doi:10.1016/S0140-6736(85)91011-6

Acquired immunodeficiency syndrome in the child of a haemophiliac

Margaret V. Ragni, Sharon Kiernan, Bernard Cohen, Alan Winkelstein, Basil Z. Zitelli, Franklin A. Bontempo, Andrew H. Urbach, Joseph Stambouli, Bruce S. Rabin, J. Carlton Gartner, J. Jeffrey Malatack, Joel A. Spero, Jessica H. Lewis

Research output: Contribution to journal › Letter › peer-review

20 Scopus citations

Abstract

Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.

Original language	English (US)
Pages (from-to)	133-135
Number of pages	3
Journal	Lancet
Volume	1
Issue number	8421
DOIs	https://doi.org/10.1016/S0140-6736(85)91011-6
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Acquired immunodeficiency syndrome in the child of a haemophiliac",

abstract = "Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.",

author = "Ragni, {Margaret V.} and Sharon Kiernan and Bernard Cohen and Alan Winkelstein and Zitelli, {Basil Z.} and Bontempo, {Franklin A.} and Urbach, {Andrew H.} and Joseph Stambouli and Rabin, {Bruce S.} and Gartner, {J. Carlton} and Malatack, {J. Jeffrey} and Spero, {Joel A.} and Lewis, {Jessica H.}",

year = "1985",

doi = "10.1016/S0140-6736(85)91011-6",

language = "English (US)",

volume = "1",

pages = "133--135",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8421",

}

TY - JOUR

T1 - Acquired immunodeficiency syndrome in the child of a haemophiliac

AU - Ragni, Margaret V.

AU - Kiernan, Sharon

AU - Cohen, Bernard

AU - Winkelstein, Alan

AU - Zitelli, Basil Z.

AU - Bontempo, Franklin A.

AU - Urbach, Andrew H.

AU - Stambouli, Joseph

AU - Rabin, Bruce S.

AU - Gartner, J. Carlton

AU - Malatack, J. Jeffrey

AU - Spero, Joel A.

AU - Lewis, Jessica H.

PY - 1985

Y1 - 1985

N2 - Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.

AB - Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.

UR - http://www.scopus.com/inward/record.url?scp=0021928139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021928139&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(85)91011-6

DO - 10.1016/S0140-6736(85)91011-6

M3 - Letter

C2 - 2857214

AN - SCOPUS:0021928139

SN - 0140-6736

VL - 1

SP - 133

EP - 135

JO - Lancet

JF - Lancet

IS - 8421

ER -

Acquired immunodeficiency syndrome in the child of a haemophiliac

Abstract

ASJC Scopus subject areas

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