Acquired immunodeficiency syndrome in the child of a haemophiliac

Margaret V. Ragni, Sharon Kiernan, Bernard A Cohen, Alan Winkelstein, Basil Z. Zitelli, Franklin A. Bontempo, Andrew H. Urbach, Joseph Stambouli, Bruce S. Rabin, J. Carlton Gartner, J. Jeffrey Malatack, Joel A. Spero, Jessica H. Lewis

Research output: Contribution to journalArticle

Abstract

Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.

Original languageEnglish (US)
Pages (from-to)133-135
Number of pages3
JournalThe Lancet
Volume1
Issue number8421
DOIs
StatePublished - 1985
Externally publishedYes

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Acquired Immunodeficiency Syndrome
Nuclear Family
Spouses
Mothers
Oral Candidiasis
Interstitial Lung Diseases
Factor VIII
Hemophilia A
Parents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ragni, M. V., Kiernan, S., Cohen, B. A., Winkelstein, A., Zitelli, B. Z., Bontempo, F. A., ... Lewis, J. H. (1985). Acquired immunodeficiency syndrome in the child of a haemophiliac. The Lancet, 1(8421), 133-135. https://doi.org/10.1016/S0140-6736(85)91011-6

Acquired immunodeficiency syndrome in the child of a haemophiliac. / Ragni, Margaret V.; Kiernan, Sharon; Cohen, Bernard A; Winkelstein, Alan; Zitelli, Basil Z.; Bontempo, Franklin A.; Urbach, Andrew H.; Stambouli, Joseph; Rabin, Bruce S.; Gartner, J. Carlton; Malatack, J. Jeffrey; Spero, Joel A.; Lewis, Jessica H.

In: The Lancet, Vol. 1, No. 8421, 1985, p. 133-135.

Research output: Contribution to journalArticle

Ragni, MV, Kiernan, S, Cohen, BA, Winkelstein, A, Zitelli, BZ, Bontempo, FA, Urbach, AH, Stambouli, J, Rabin, BS, Gartner, JC, Malatack, JJ, Spero, JA & Lewis, JH 1985, 'Acquired immunodeficiency syndrome in the child of a haemophiliac', The Lancet, vol. 1, no. 8421, pp. 133-135. https://doi.org/10.1016/S0140-6736(85)91011-6
Ragni MV, Kiernan S, Cohen BA, Winkelstein A, Zitelli BZ, Bontempo FA et al. Acquired immunodeficiency syndrome in the child of a haemophiliac. The Lancet. 1985;1(8421):133-135. https://doi.org/10.1016/S0140-6736(85)91011-6
Ragni, Margaret V. ; Kiernan, Sharon ; Cohen, Bernard A ; Winkelstein, Alan ; Zitelli, Basil Z. ; Bontempo, Franklin A. ; Urbach, Andrew H. ; Stambouli, Joseph ; Rabin, Bruce S. ; Gartner, J. Carlton ; Malatack, J. Jeffrey ; Spero, Joel A. ; Lewis, Jessica H. / Acquired immunodeficiency syndrome in the child of a haemophiliac. In: The Lancet. 1985 ; Vol. 1, No. 8421. pp. 133-135.
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