Acquired immunity to malaria was investigated in mice which had recovered from a primary infection with P. b. yoelii. It was found that antibody synthesis and protection persisted at least 17 months, although both decreased somewhat during this interval. Strong cross-protection was exhibited against a virulent isolate of the parent strain but not against the type species, P. b. berghei. It was not possible to detect persisting antigen or persisting infectious organisms in immune mice; both blood-induced and sporozoite- induced infections were followed from this standpoint.
|Original language||English (US)|
|Number of pages||5|
|Journal||Transactions of the Royal Society of Tropical Medicine and Hygiene|
|State||Published - Jan 1 1971|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Infectious Diseases