Acquired immunity to plasmodium berghei yoelii in mice

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Acquired immunity to malaria was investigated in mice which had recovered from a primary infection with P. b. yoelii. It was found that antibody synthesis and protection persisted at least 17 months, although both decreased somewhat during this interval. Strong cross-protection was exhibited against a virulent isolate of the parent strain but not against the type species, P. b. berghei. It was not possible to detect persisting antigen or persisting infectious organisms in immune mice; both blood-induced and sporozoite- induced infections were followed from this standpoint.

Original languageEnglish (US)
Pages (from-to)586-590
Number of pages5
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Issue number5
StatePublished - 1971
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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