Acidosis and arrhythmias in cardiac muscle

Clive H. Orchard, Horacio E. Cingolani

Research output: Contribution to journalArticle

Abstract

Acidosis is a well recognised consequences of myocardial ischaemia. In this brief article we have reviewed the consequences of acidosis that might be arrhythmogenic. These include early afterdepolarisations and triggered activity, delayed afterdepolarisations, pulsus alternans, and reentry. In each case we have described the evidence that acidosis can provoke such behaviour and then discussed the possible mechanisms and consequences of each behaviour. It seems likely that chanes of pH may contribute to arrythmogenesis during ischaemia by these mechanisms.

Original languageEnglish (US)
Pages (from-to)1312-1319
Number of pages8
JournalCardiovascular Research
Volume28
Issue number9
StatePublished - Sep 1994
Externally publishedYes

Fingerprint

Cardiac muscle
Arrhythmia
Reentry
Acidosis
Muscle
Cardiac Arrhythmias
Myocardium
Myocardial Ischemia
Ischemia
Likely
Pulse
Evidence

Keywords

  • acidosis
  • arrhythmias
  • calcium
  • cardiac muscle
  • electrophysiology
  • pH

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Cite this

Orchard, C. H., & Cingolani, H. E. (1994). Acidosis and arrhythmias in cardiac muscle. Cardiovascular Research, 28(9), 1312-1319.

Acidosis and arrhythmias in cardiac muscle. / Orchard, Clive H.; Cingolani, Horacio E.

In: Cardiovascular Research, Vol. 28, No. 9, 09.1994, p. 1312-1319.

Research output: Contribution to journalArticle

Orchard, CH & Cingolani, HE 1994, 'Acidosis and arrhythmias in cardiac muscle', Cardiovascular Research, vol. 28, no. 9, pp. 1312-1319.
Orchard CH, Cingolani HE. Acidosis and arrhythmias in cardiac muscle. Cardiovascular Research. 1994 Sep;28(9):1312-1319.
Orchard, Clive H. ; Cingolani, Horacio E. / Acidosis and arrhythmias in cardiac muscle. In: Cardiovascular Research. 1994 ; Vol. 28, No. 9. pp. 1312-1319.
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