Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation

Zhou Zhu, Tao Zheng, Robert J. Homer, Yoon Keun Kim, Ning Yuan Chen, Lauren Cohn, Qutayba Hamid, Jack A. Elias

Research output: Contribution to journalArticle

Abstract

Chitin is a surface component of parasites and insects, and chitinases are induced in lower life forms during infections with these agents. Although chitin itself does not exist in humans, chitinases are present in the human genome. We show here that acidic mammalian chitinase (AMCase) is induced via a T helper-2 (Th2)-specific, interleukin-13 (IL-13)-mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma. AMCase neutralization ameliorated Th2 inflammation and airway hyperresponsiveness, in part by inhibiting IL-13 pathway activation and chemokine induction. AMCase may thus be an important mediator of IL-13-induced responses in Th2-dominated disorders such as asthma.

Original languageEnglish (US)
Pages (from-to)1678-1682
Number of pages5
JournalScience
Volume304
Issue number5677
DOIs
StatePublished - Jun 11 2004
Externally publishedYes

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Chitinases
Interleukin-13
Inflammation
Chitin
Asthma
Human Genome
Chemokines
Insects
Parasites
Epithelial Cells
Macrophages
Infection

ASJC Scopus subject areas

  • General

Cite this

Zhu, Z., Zheng, T., Homer, R. J., Kim, Y. K., Chen, N. Y., Cohn, L., ... Elias, J. A. (2004). Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science, 304(5677), 1678-1682. https://doi.org/10.1126/science.1095336

Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. / Zhu, Zhou; Zheng, Tao; Homer, Robert J.; Kim, Yoon Keun; Chen, Ning Yuan; Cohn, Lauren; Hamid, Qutayba; Elias, Jack A.

In: Science, Vol. 304, No. 5677, 11.06.2004, p. 1678-1682.

Research output: Contribution to journalArticle

Zhu, Z, Zheng, T, Homer, RJ, Kim, YK, Chen, NY, Cohn, L, Hamid, Q & Elias, JA 2004, 'Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation', Science, vol. 304, no. 5677, pp. 1678-1682. https://doi.org/10.1126/science.1095336
Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science. 2004 Jun 11;304(5677):1678-1682. https://doi.org/10.1126/science.1095336
Zhu, Zhou ; Zheng, Tao ; Homer, Robert J. ; Kim, Yoon Keun ; Chen, Ning Yuan ; Cohn, Lauren ; Hamid, Qutayba ; Elias, Jack A. / Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. In: Science. 2004 ; Vol. 304, No. 5677. pp. 1678-1682.
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