Acid-promoted olefination of ketones by an iron(III) porphyrin complex

Ying Chen, Lingyu Huang, X. Peter Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

(Matrix presented) The acid-promoted olefination of unactivated ketones with diazo reagents in the presence of triphenylphosphine can be catalyzed by the commercially available iron(III) porphyrin complex Fe(TPP)Cl. The reactions were effectively carried out under mild conditions in a one-pot fashion with the use of a stoichiometric diazo reagents and substoichiometric benzoic acid. Examples include aromatic, aliphatic, cyclic, and unsaturated ketones with ethyl diazoacetate or tert-butyl diazoacetate.

Original languageEnglish (US)
Pages (from-to)2493-2496
Number of pages4
JournalOrganic Letters
Volume5
Issue number14
DOIs
StatePublished - Jul 10 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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