Acid phosphatase positivity in childhood acute lymphocytic leukemia

D. R. Head, M. Borowitz, L. Cerezo, C. M. Craven, B. L. Brock, J. M. Boyett, D. J. Pullen, W. M. Crist, J. Falletta, G. B. Humphrey

Research output: Contribution to journalArticlepeer-review


The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.

Original languageEnglish (US)
Pages (from-to)650-653
Number of pages4
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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