Acid phosphatase positivity in childhood acute lymphocytic leukemia

D. R. Head; M. Borowitz; L. Cerezo; C. M. Craven; B. L. Brock; J. M. Boyett; D. J. Pullen; W. M. Crist; J. Falletta; G. B. Humphrey

doi:10.1093/ajcp/86.5.650

Acid phosphatase positivity in childhood acute lymphocytic leukemia

D. R. Head, M. Borowitz, L. Cerezo, C. M. Craven, B. L. Brock, J. M. Boyett, D. J. Pullen, W. M. Crist, J. Falletta, G. B. Humphrey

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Abstract

The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.

Original language	English (US)
Pages (from-to)	650-653
Number of pages	4
Journal	American journal of clinical pathology
Volume	86
Issue number	5
DOIs	https://doi.org/10.1093/ajcp/86.5.650
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1093/ajcp/86.5.650

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title = "Acid phosphatase positivity in childhood acute lymphocytic leukemia",

abstract = "The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.",

author = "Head, {D. R.} and M. Borowitz and L. Cerezo and Craven, {C. M.} and Brock, {B. L.} and Boyett, {J. M.} and Pullen, {D. J.} and Crist, {W. M.} and J. Falletta and Humphrey, {G. B.}",

year = "1986",

doi = "10.1093/ajcp/86.5.650",

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TY - JOUR

T1 - Acid phosphatase positivity in childhood acute lymphocytic leukemia

AU - Head, D. R.

AU - Borowitz, M.

AU - Cerezo, L.

AU - Craven, C. M.

AU - Brock, B. L.

AU - Boyett, J. M.

AU - Pullen, D. J.

AU - Crist, W. M.

AU - Falletta, J.

AU - Humphrey, G. B.

PY - 1986

Y1 - 1986

N2 - The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.

AB - The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.

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IS - 5

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Acid phosphatase positivity in childhood acute lymphocytic leukemia

Abstract

ASJC Scopus subject areas

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