Acid infusion into the esophagus increases the number of meal-induced transient lower esophageal sphincter relaxations (TLESRs) in healthy volunteers

J. Halicka, P. Banovcin, M. Halickova, M. Demeter, R. Hyrdel, M. Tatar, M. Kollarik

Research output: Contribution to journalArticle

Abstract

Background: Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism of gastroesophageal reflux (GER) but the regulation of TLESR by stimuli in the esophagus is incompletely understood. If stimuli in the esophagus can influence TLESR, then such regulation may perpetuate or limit GER. We addressed the hypothesis that acid in the esophagus enhances TLESRs. Methods: We evaluated the effect of acid infusion into the distal esophagus on TLESRs evoked by a standard meal in a paired randomized study in healthy subjects. TLESRs were evaluated by using high resolution manometry (HRM). Key Results: We found that acid in the esophagus enhanced meal-induced TLESRs. Compared to control infusion the number of TLESRs (median [interquartile range]) was increased during 2 h following the acid infusion (11 [9-14] vs 17 [12.5-20], p 

Original languageEnglish (US)
Pages (from-to)1469-1476
Number of pages8
JournalNeurogastroenterology and Motility
Volume26
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Acid
  • Esophagus
  • Gastroesophageal reflux
  • Transient lower esophageal sphincter relaxation
  • Vagus nerve

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology
  • Medicine(all)

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