Achieving high-resolution, soft-tissue imaging with cone-beam CT

A two-pronged approach for modulation of x-ray fluence and detector gain

S. A. Graham, Jeff Siewerdsen, D. J. Moseley, H. Keller, N. A. Shkumat, D. A. Jaffray

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cone-beam computed tomography (CBCT) presents a highly promising and challenging advanced application of flat-panel detectors (FPDs). The great advantage of this adaptable technology is in the potential for sub-mm 3D spatial resolution in combination with soft-tissue detectability. While the former is achieved naturally by CBCT systems incorporating modern FPD designs (e.g., 200-400 um pixel pitch), the latter presents a significant challenge due to limitations in FPD dynamic range, large field of view, and elevated levels of x-ray scatter in typical CBCT configurations. We are investigating a two-pronged strategy to maximizing soft-tissue detectability in CBCT: 1.) front-end solutions, including novel beam modulation designs (viz., spatially varying compensators) that alleviate detector dynamic range requirements, reduce x-ray scatter, and better distribute imaging dose in a manner suited to soft-tissue visualization throughout the field of view; and 2.) back-end solutions, including implementation of an advanced FPD design (Varian PaxScan 4030CB) that features dual-gain and dynamic gain switching that effectively extends detector dynamic range to 18 bits. These strategies are explored quantitatively on CBCT imaging platforms developed in our laboratory, including a dedicated CBCT bench and a mobile isocentric C-arm (Siemens PowerMobil). Pre-clinical evaluation of improved soft-tissue visibility was carried out in phantom and patient imaging with the C-arm device. Incorporation of these strategies begin to reveal the full potential of CBCT for soft-tissue visualization, an essential step in realizing broad utility of this adaptable technology for diagnostic and image-guided procedures.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsM.J. Flynn
Pages198-206
Number of pages9
Volume5745
EditionI
DOIs
StatePublished - 2005
Externally publishedYes
EventMedical Imaging 2005 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 13 2005Feb 15 2005

Other

OtherMedical Imaging 2005 - Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/13/052/15/05

Fingerprint

Tomography
Cones
Modulation
Tissue
Detectors
Imaging techniques
X rays
Visualization
Visibility
Dosimetry
Pixels

Keywords

  • Bow-tie
  • C-arm
  • Cone-beam CT
  • Contrast-to-noise
  • Dose
  • Dual-gain
  • Dynamic range
  • Flat panel
  • Scatter

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Graham, S. A., Siewerdsen, J., Moseley, D. J., Keller, H., Shkumat, N. A., & Jaffray, D. A. (2005). Achieving high-resolution, soft-tissue imaging with cone-beam CT: A two-pronged approach for modulation of x-ray fluence and detector gain. In M. J. Flynn (Ed.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (I ed., Vol. 5745, pp. 198-206). [25] https://doi.org/10.1117/12.595886

Achieving high-resolution, soft-tissue imaging with cone-beam CT : A two-pronged approach for modulation of x-ray fluence and detector gain. / Graham, S. A.; Siewerdsen, Jeff; Moseley, D. J.; Keller, H.; Shkumat, N. A.; Jaffray, D. A.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / M.J. Flynn. Vol. 5745 I. ed. 2005. p. 198-206 25.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Graham, SA, Siewerdsen, J, Moseley, DJ, Keller, H, Shkumat, NA & Jaffray, DA 2005, Achieving high-resolution, soft-tissue imaging with cone-beam CT: A two-pronged approach for modulation of x-ray fluence and detector gain. in MJ Flynn (ed.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. I edn, vol. 5745, 25, pp. 198-206, Medical Imaging 2005 - Physics of Medical Imaging, San Diego, CA, United States, 2/13/05. https://doi.org/10.1117/12.595886
Graham SA, Siewerdsen J, Moseley DJ, Keller H, Shkumat NA, Jaffray DA. Achieving high-resolution, soft-tissue imaging with cone-beam CT: A two-pronged approach for modulation of x-ray fluence and detector gain. In Flynn MJ, editor, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. I ed. Vol. 5745. 2005. p. 198-206. 25 https://doi.org/10.1117/12.595886
Graham, S. A. ; Siewerdsen, Jeff ; Moseley, D. J. ; Keller, H. ; Shkumat, N. A. ; Jaffray, D. A. / Achieving high-resolution, soft-tissue imaging with cone-beam CT : A two-pronged approach for modulation of x-ray fluence and detector gain. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / M.J. Flynn. Vol. 5745 I. ed. 2005. pp. 198-206
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