Achieving cannabis cessation - Evaluating N-acetylcysteine treatment (ACCENT): Design and implementation of a multi-site, randomized controlled study in the national institute on drug abuse clinical trials network

Erin A. McClure, Susan C. Sonne, Theresa Winhusen, Kathleen M. Carroll, Udi E. Ghitza, Aimee L. McRae-Clark, Abigail G. Matthews, Gaurav Sharma, Paul Van Veldhuisen, Ryan G. Vandrey, Frances R. Levin, Roger D. Weiss, Robert Lindblad, Colleen Allen, Larissa J. Mooney, Louise Haynes, Gregory S. Brigham, Steve Sparenborg, Albert L. Hasson, Kevin M. Gray

Research output: Contribution to journalArticlepeer-review

Abstract

Despite recent advances in behavioral interventions for cannabis use disorders, effect sizes remain modest, and few individuals achieve long-term abstinence. One strategy to enhance outcomes is the addition of pharmacotherapy to complement behavioral treatment, but to date no efficacious medications targeting cannabis use disorders in adults through large, randomized controlled trials have been identified. The National Institute on Drug Abuse Clinical Trials Network (NIDA CTN) is currently conducting a study to test the efficacy of N-acetylcysteine (NAC) versus placebo (PBO), added to contingency management, for cannabis cessation in adults (ages 18-50). This study was designed to replicate positive findings from a study in cannabis-dependent adolescents that found greater odds of abstinence with NAC compared to PBO. This paper describes the design and implementation of an ongoing 12-week, intent-to-treat, double-blind, randomized, placebo-controlled study with one follow-up visit four weeks post-treatment. Approximately 300 treatment-seeking cannabis-dependent adults will be randomized to NAC or PBO across six study sites in the United States. The primary objective of this 12-week study is to evaluate the efficacy of twice-daily orally-administered NAC (1200. mg) versus matched PBO, added to contingency management, on cannabis abstinence. NAC is among the first medications to demonstrate increased odds of abstinence in a randomized controlled study among cannabis users in any age group. The current study will assess the cannabis cessation efficacy of NAC combined with a behavioral intervention in adults, providing a novel and timely contribution to the evidence base for the treatment of cannabis use disorders.

Original languageEnglish (US)
Pages (from-to)211-223
Number of pages13
JournalContemporary Clinical Trials
Volume39
Issue number2
DOIs
StatePublished - Nov 1 2014

Keywords

  • Cannabis
  • Clinical study design
  • Marijuana
  • N-acetylcysteine
  • Pharmacotherapy
  • Randomized trials

ASJC Scopus subject areas

  • Pharmacology (medical)

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