Achievements and challenges in composite tissue allotransplantation

Stefan Schneeberger; Luis Landin; Jerzy Jableki; Peter Butler; Christoph Hoehnke; Gerald Brandacher; Emmanuel Morelon

doi:10.1111/j.1432-2277.2011.01261.x

Achievements and challenges in composite tissue allotransplantation

Stefan Schneeberger, Luis Landin, Jerzy Jableki, Peter Butler, Christoph Hoehnke, Gerald Brandacher, Emmanuel Morelon

School of Medicine

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Overall, more than 60 hand/forearm/arm transplantations and 16 face transplantations have been performed in the past 12 years. In the European experience summarized here, three grafts have been lost in response to a vascular thrombosis (n = 1), rejection and incompliance with immunosuppression (n = 1) and death (n = 1). The overall functional and esthetic outcome is very satisfactory, but serious side effects and complications related to immunosuppression are challenges hindering progress in this field. The high levels of immunosuppression, skin rejection, nerve regeneration, donor legislation and the acceptance level need to be addressed to promote growth of this promising new field in transplantation and reconstructive surgery.

Original language	English (US)
Pages (from-to)	760-769
Number of pages	10
Journal	Transplant International
Volume	24
Issue number	8
DOIs	https://doi.org/10.1111/j.1432-2277.2011.01261.x
State	Published - Aug 2011

Keywords

composite tissue transplantation
face transplantation
hand transplantation
indications
outcome
rejection

ASJC Scopus subject areas

Transplantation

Access to Document

10.1111/j.1432-2277.2011.01261.x

Cite this

@article{349c0fe2da2a4b759fb7b90e77a15206,

title = "Achievements and challenges in composite tissue allotransplantation",

abstract = "Overall, more than 60 hand/forearm/arm transplantations and 16 face transplantations have been performed in the past 12 years. In the European experience summarized here, three grafts have been lost in response to a vascular thrombosis (n = 1), rejection and incompliance with immunosuppression (n = 1) and death (n = 1). The overall functional and esthetic outcome is very satisfactory, but serious side effects and complications related to immunosuppression are challenges hindering progress in this field. The high levels of immunosuppression, skin rejection, nerve regeneration, donor legislation and the acceptance level need to be addressed to promote growth of this promising new field in transplantation and reconstructive surgery.",

keywords = "composite tissue transplantation, face transplantation, hand transplantation, indications, outcome, rejection",

author = "Stefan Schneeberger and Luis Landin and Jerzy Jableki and Peter Butler and Christoph Hoehnke and Gerald Brandacher and Emmanuel Morelon",

year = "2011",

month = aug,

doi = "10.1111/j.1432-2277.2011.01261.x",

language = "English (US)",

volume = "24",

pages = "760--769",

journal = "Transplant International",

issn = "0934-0874",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Achievements and challenges in composite tissue allotransplantation

AU - Schneeberger, Stefan

AU - Landin, Luis

AU - Jableki, Jerzy

AU - Butler, Peter

AU - Hoehnke, Christoph

AU - Brandacher, Gerald

AU - Morelon, Emmanuel

PY - 2011/8

Y1 - 2011/8

N2 - Overall, more than 60 hand/forearm/arm transplantations and 16 face transplantations have been performed in the past 12 years. In the European experience summarized here, three grafts have been lost in response to a vascular thrombosis (n = 1), rejection and incompliance with immunosuppression (n = 1) and death (n = 1). The overall functional and esthetic outcome is very satisfactory, but serious side effects and complications related to immunosuppression are challenges hindering progress in this field. The high levels of immunosuppression, skin rejection, nerve regeneration, donor legislation and the acceptance level need to be addressed to promote growth of this promising new field in transplantation and reconstructive surgery.

AB - Overall, more than 60 hand/forearm/arm transplantations and 16 face transplantations have been performed in the past 12 years. In the European experience summarized here, three grafts have been lost in response to a vascular thrombosis (n = 1), rejection and incompliance with immunosuppression (n = 1) and death (n = 1). The overall functional and esthetic outcome is very satisfactory, but serious side effects and complications related to immunosuppression are challenges hindering progress in this field. The high levels of immunosuppression, skin rejection, nerve regeneration, donor legislation and the acceptance level need to be addressed to promote growth of this promising new field in transplantation and reconstructive surgery.

KW - composite tissue transplantation

KW - face transplantation

KW - hand transplantation

KW - indications

KW - outcome

KW - rejection

UR - http://www.scopus.com/inward/record.url?scp=79960138137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960138137&partnerID=8YFLogxK

U2 - 10.1111/j.1432-2277.2011.01261.x

DO - 10.1111/j.1432-2277.2011.01261.x

M3 - Review article

C2 - 21554424

AN - SCOPUS:79960138137

SN - 0934-0874

VL - 24

SP - 760

EP - 769

JO - Transplant International

JF - Transplant International

IS - 8

ER -

Achievements and challenges in composite tissue allotransplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this