Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer

Research output: Contribution to journalArticle

Abstract

Achaete-scute homolog-1 (termed Mash1 in rodents, hASH1 in humans) is a basic helix-loop-helix transcription factor important in early development of neural and neuroendocrine (NE) progenitor cells in multiple tissues including the CNS, autonomic nervous system, adrenal medulla, thyroid, lung, and prostate, among others. This review discusses how progress in developmental neurobiology of Mash1 has translated into novel insights in NE tumor biology, particularly for small cell lung cancer. Inhibition of this factor by the Notch pathway is essential in regulating NE commitment in airway epithelial precursor cells, and may play a comparable role in modulating phenotypes of lung cancer and other tumors.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalCancer Letters
Volume204
Issue number2
DOIs
StatePublished - Feb 20 2004

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Basic Helix-Loop-Helix Transcription Factors
Neuroendocrine Cells
Adrenal Medulla
Neuroendocrine Tumors
Neurobiology
Autonomic Nervous System
Small Cell Lung Carcinoma
Prostate
Rodentia
Lung Neoplasms
Thyroid Gland
Stem Cells
Epithelial Cells
Phenotype
Lung
Neoplasms

Keywords

  • Hairy-enhancer of split 1
  • hASH1
  • Lung cancer
  • Lung development
  • Mammalian achaete-scute homolog-1
  • Neuroendocrine
  • Notch

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer. / Ball, Douglas W.

In: Cancer Letters, Vol. 204, No. 2, 20.02.2004, p. 159-169.

Research output: Contribution to journalArticle

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