Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer

Douglas W. Ball

doi:10.1016/S0304-3835(03)00452-X

Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer

Douglas W. Ball

School of Medicine

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Achaete-scute homolog-1 (termed Mash1 in rodents, hASH1 in humans) is a basic helix-loop-helix transcription factor important in early development of neural and neuroendocrine (NE) progenitor cells in multiple tissues including the CNS, autonomic nervous system, adrenal medulla, thyroid, lung, and prostate, among others. This review discusses how progress in developmental neurobiology of Mash1 has translated into novel insights in NE tumor biology, particularly for small cell lung cancer. Inhibition of this factor by the Notch pathway is essential in regulating NE commitment in airway epithelial precursor cells, and may play a comparable role in modulating phenotypes of lung cancer and other tumors.

Original language	English (US)
Pages (from-to)	159-169
Number of pages	11
Journal	Cancer Letters
Volume	204
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(03)00452-X
State	Published - Feb 20 2004

Keywords

Hairy-enhancer of split 1
Lung cancer
Lung development
Mammalian achaete-scute homolog-1
Neuroendocrine
Notch
hASH1

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/S0304-3835(03)00452-X

Cite this

@article{eece8f5c6d1f488d847148f3e19aa5bb,

title = "Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer",

abstract = "Achaete-scute homolog-1 (termed Mash1 in rodents, hASH1 in humans) is a basic helix-loop-helix transcription factor important in early development of neural and neuroendocrine (NE) progenitor cells in multiple tissues including the CNS, autonomic nervous system, adrenal medulla, thyroid, lung, and prostate, among others. This review discusses how progress in developmental neurobiology of Mash1 has translated into novel insights in NE tumor biology, particularly for small cell lung cancer. Inhibition of this factor by the Notch pathway is essential in regulating NE commitment in airway epithelial precursor cells, and may play a comparable role in modulating phenotypes of lung cancer and other tumors.",

keywords = "Hairy-enhancer of split 1, Lung cancer, Lung development, Mammalian achaete-scute homolog-1, Neuroendocrine, Notch, hASH1",

author = "Ball, {Douglas W.}",

note = "Funding Information: Supported in part by National Cancer Institute grant R0-CA70244 and a Charlotte Geyer Foundation award. ",

year = "2004",

month = feb,

day = "20",

doi = "10.1016/S0304-3835(03)00452-X",

language = "English (US)",

volume = "204",

pages = "159--169",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer

AU - Ball, Douglas W.

N1 - Funding Information: Supported in part by National Cancer Institute grant R0-CA70244 and a Charlotte Geyer Foundation award.

PY - 2004/2/20

Y1 - 2004/2/20

N2 - Achaete-scute homolog-1 (termed Mash1 in rodents, hASH1 in humans) is a basic helix-loop-helix transcription factor important in early development of neural and neuroendocrine (NE) progenitor cells in multiple tissues including the CNS, autonomic nervous system, adrenal medulla, thyroid, lung, and prostate, among others. This review discusses how progress in developmental neurobiology of Mash1 has translated into novel insights in NE tumor biology, particularly for small cell lung cancer. Inhibition of this factor by the Notch pathway is essential in regulating NE commitment in airway epithelial precursor cells, and may play a comparable role in modulating phenotypes of lung cancer and other tumors.

AB - Achaete-scute homolog-1 (termed Mash1 in rodents, hASH1 in humans) is a basic helix-loop-helix transcription factor important in early development of neural and neuroendocrine (NE) progenitor cells in multiple tissues including the CNS, autonomic nervous system, adrenal medulla, thyroid, lung, and prostate, among others. This review discusses how progress in developmental neurobiology of Mash1 has translated into novel insights in NE tumor biology, particularly for small cell lung cancer. Inhibition of this factor by the Notch pathway is essential in regulating NE commitment in airway epithelial precursor cells, and may play a comparable role in modulating phenotypes of lung cancer and other tumors.

KW - Hairy-enhancer of split 1

KW - Lung cancer

KW - Lung development

KW - Mammalian achaete-scute homolog-1

KW - Neuroendocrine

KW - Notch

KW - hASH1

UR - http://www.scopus.com/inward/record.url?scp=0842287503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842287503&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(03)00452-X

DO - 10.1016/S0304-3835(03)00452-X

M3 - Article

C2 - 15013215

AN - SCOPUS:0842287503

SN - 0304-3835

VL - 204

SP - 159

EP - 169

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this