Acetylenic pyridines for use in PET imaging of nicotinic receptors

Alan P. Kozikowski, Sheela K. Chellappan, David Henderson, Roger Fulton, Nicolas Giboureau, Yingxian Xiao, Zhi Liang Wei, Denis Guilloteau, Patrick Emond, Frederic Dolle, Kenneth J. Kellar, Michael Kassiou

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalChemMedChem
Volume2
Issue number1
DOIs
StatePublished - Jan 15 2007
Externally publishedYes

Fingerprint

Pyridines
Nicotinic Receptors
3-(2-(pyrrolidinyl)methoxy)pyridine
Bearings (structural)
Imaging techniques
Acetylene
Papio
Nervous System Diseases
Derivatives

Keywords

  • α4β2 receptors
  • Acetylenic pyridines
  • Imaging agents
  • nAChR
  • PET

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

Cite this

Kozikowski, A. P., Chellappan, S. K., Henderson, D., Fulton, R., Giboureau, N., Xiao, Y., ... Kassiou, M. (2007). Acetylenic pyridines for use in PET imaging of nicotinic receptors. ChemMedChem, 2(1), 54-57. https://doi.org/10.1002/cmdc.200600220

Acetylenic pyridines for use in PET imaging of nicotinic receptors. / Kozikowski, Alan P.; Chellappan, Sheela K.; Henderson, David; Fulton, Roger; Giboureau, Nicolas; Xiao, Yingxian; Wei, Zhi Liang; Guilloteau, Denis; Emond, Patrick; Dolle, Frederic; Kellar, Kenneth J.; Kassiou, Michael.

In: ChemMedChem, Vol. 2, No. 1, 15.01.2007, p. 54-57.

Research output: Contribution to journalArticle

Kozikowski, AP, Chellappan, SK, Henderson, D, Fulton, R, Giboureau, N, Xiao, Y, Wei, ZL, Guilloteau, D, Emond, P, Dolle, F, Kellar, KJ & Kassiou, M 2007, 'Acetylenic pyridines for use in PET imaging of nicotinic receptors', ChemMedChem, vol. 2, no. 1, pp. 54-57. https://doi.org/10.1002/cmdc.200600220
Kozikowski AP, Chellappan SK, Henderson D, Fulton R, Giboureau N, Xiao Y et al. Acetylenic pyridines for use in PET imaging of nicotinic receptors. ChemMedChem. 2007 Jan 15;2(1):54-57. https://doi.org/10.1002/cmdc.200600220
Kozikowski, Alan P. ; Chellappan, Sheela K. ; Henderson, David ; Fulton, Roger ; Giboureau, Nicolas ; Xiao, Yingxian ; Wei, Zhi Liang ; Guilloteau, Denis ; Emond, Patrick ; Dolle, Frederic ; Kellar, Kenneth J. ; Kassiou, Michael. / Acetylenic pyridines for use in PET imaging of nicotinic receptors. In: ChemMedChem. 2007 ; Vol. 2, No. 1. pp. 54-57.
@article{18c379e9774e4a4b84761b5012bac5b5,
title = "Acetylenic pyridines for use in PET imaging of nicotinic receptors",
abstract = "(Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.",
keywords = "α4β2 receptors, Acetylenic pyridines, Imaging agents, nAChR, PET",
author = "Kozikowski, {Alan P.} and Chellappan, {Sheela K.} and David Henderson and Roger Fulton and Nicolas Giboureau and Yingxian Xiao and Wei, {Zhi Liang} and Denis Guilloteau and Patrick Emond and Frederic Dolle and Kellar, {Kenneth J.} and Michael Kassiou",
year = "2007",
month = "1",
day = "15",
doi = "10.1002/cmdc.200600220",
language = "English (US)",
volume = "2",
pages = "54--57",
journal = "ChemMedChem",
issn = "1860-7179",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Acetylenic pyridines for use in PET imaging of nicotinic receptors

AU - Kozikowski, Alan P.

AU - Chellappan, Sheela K.

AU - Henderson, David

AU - Fulton, Roger

AU - Giboureau, Nicolas

AU - Xiao, Yingxian

AU - Wei, Zhi Liang

AU - Guilloteau, Denis

AU - Emond, Patrick

AU - Dolle, Frederic

AU - Kellar, Kenneth J.

AU - Kassiou, Michael

PY - 2007/1/15

Y1 - 2007/1/15

N2 - (Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.

AB - (Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.

KW - α4β2 receptors

KW - Acetylenic pyridines

KW - Imaging agents

KW - nAChR

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=34547560608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547560608&partnerID=8YFLogxK

U2 - 10.1002/cmdc.200600220

DO - 10.1002/cmdc.200600220

M3 - Article

C2 - 17096450

AN - SCOPUS:34547560608

VL - 2

SP - 54

EP - 57

JO - ChemMedChem

JF - ChemMedChem

SN - 1860-7179

IS - 1

ER -