Acetylenic pyridines for use in PET imaging of nicotinic receptors

Alan P. Kozikowski, Sheela K. Chellappan, David Henderson, Roger Fulton, Nicolas Giboureau, Yingxian Xiao, Zhi Liang Wei, Denis Guilloteau, Patrick Emond, Frederic Dolle, Kenneth J. Kellar, Michael Kassiou

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalChemMedChem
Volume2
Issue number1
DOIs
StatePublished - Jan 15 2007

Keywords

  • Acetylenic pyridines
  • Imaging agents
  • PET
  • nAChR
  • α4β2 receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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  • Cite this

    Kozikowski, A. P., Chellappan, S. K., Henderson, D., Fulton, R., Giboureau, N., Xiao, Y., Wei, Z. L., Guilloteau, D., Emond, P., Dolle, F., Kellar, K. J., & Kassiou, M. (2007). Acetylenic pyridines for use in PET imaging of nicotinic receptors. ChemMedChem, 2(1), 54-57. https://doi.org/10.1002/cmdc.200600220