Acetylenic pyridines for use in PET imaging of nicotinic receptors

Alan P. Kozikowski; Sheela K. Chellappan; David Henderson; Roger Fulton; Nicolas Giboureau; Yingxian Xiao; Zhi Liang Wei; Denis Guilloteau; Patrick Emond; Frederic Dolle; Kenneth J. Kellar; Michael Kassiou

doi:10.1002/cmdc.200600220

Acetylenic pyridines for use in PET imaging of nicotinic receptors

Alan P. Kozikowski, Sheela K. Chellappan, David Henderson, Roger Fulton, Nicolas Giboureau, Yingxian Xiao, Zhi Liang Wei, Denis Guilloteau, Patrick Emond, Frederic Dolle, Kenneth J. Kellar, Michael Kassiou

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

(Chemical Equation Presented) Getting a better view: ¹¹C- and ¹⁸F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.

Original language	English (US)
Pages (from-to)	54-57
Number of pages	4
Journal	ChemMedChem
Volume	2
Issue number	1
DOIs	https://doi.org/10.1002/cmdc.200600220
State	Published - Jan 15 2007
Externally published	Yes

Keywords

Acetylenic pyridines
Imaging agents
PET
nAChR
α4β2 receptors

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1002/cmdc.200600220

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abstract = "(Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.",

keywords = "Acetylenic pyridines, Imaging agents, PET, nAChR, α4β2 receptors",

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AU - Kozikowski, Alan P.

AU - Chellappan, Sheela K.

AU - Henderson, David

AU - Fulton, Roger

AU - Giboureau, Nicolas

AU - Xiao, Yingxian

AU - Wei, Zhi Liang

AU - Guilloteau, Denis

AU - Emond, Patrick

AU - Dolle, Frederic

AU - Kellar, Kenneth J.

AU - Kassiou, Michael

PY - 2007/1/15

Y1 - 2007/1/15

N2 - (Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.

AB - (Chemical Equation Presented) Getting a better view: 11C- and 18F-labeled derivatives of the α4β2-selective, acetylene-bearing analogue of A-84543 were prepared and examined for their use as diagnostic tools in the PET imaging of nicotinic receptors in baboons. These agents may find use in determining nicotinic receptor changes in certain neurological disorders.

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KW - Imaging agents

KW - PET

KW - nAChR

KW - α4β2 receptors

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Acetylenic pyridines for use in PET imaging of nicotinic receptors

Abstract

Keywords

ASJC Scopus subject areas

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