Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation

Robert S Fitzgerald, M. Shirahata, H. Y. Wang

Research output: Contribution to journalArticle

Abstract

Previous pharmacological, immunocytochemical, electrophysiological, and microfluorometric studies have suggested that acetylcholine (ACh) is a critically important excitatory transmitter in the chemotransduction of hypoxia by the cat carotid body (CB). With the use of HPLC this study shows that the in vitro cat CB releases ACh under normoxic conditions; this release is increased when the CB is challenged with hypoxia. The preliminary observation that greater amounts of ACh are liberated in the presence of gallamine and AFDX116 suggests the presence of functioning M2 muscarinic receptors on the glomus cells of the CB.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
JournalAdvances in Experimental Medicine and Biology
Volume475
StatePublished - 2000

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Carotid Body
Acetylcholine
Cats
Muscarinic M2 Receptors
Gallamine Triethiodide
Transmitters
High Pressure Liquid Chromatography
Pharmacology
In Vitro Techniques
Hypoxia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation. / Fitzgerald, Robert S; Shirahata, M.; Wang, H. Y.

In: Advances in Experimental Medicine and Biology, Vol. 475, 2000, p. 485-494.

Research output: Contribution to journalArticle

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