Acetylation of unsymmetrical diols in the presence of Al2O3

Gary W. Breton, Melissa J. Kurtz, Sharyn L. Kurtz

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Abstract

The effect of the presence of chromatographic grade Al2O3 on the acetylation of a series of unsymmetrical 1,5-diols was investigated. For diols containing both a primary and a secondary hydroxyl group, it was observed that higher yields of the more hindered secondary acetates were formed in the presence of Al2O3 than the corresponding reactions in solution.

Original languageEnglish (US)
Pages (from-to)3825-3828
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number22
DOIs
StatePublished - Jun 2 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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