Acetaminophen kinetics in the elderly

Marcia Divoll, Darrell R. Abernethy, Barbara Ameer, David J. Greenblatt

Research output: Contribution to journalArticle

Abstract

Thirty-two healthy men and women, 23 to 78 yr old, received single 650-mg intravenous doses of acetaminophen and the drug's kinetics were determined from multiple plasma samples drawn over the next 8 to 12 hr. Acetaminophen elimination half-life averaged 2.7 hr (range, 1.9 to 4.3 hr) and was not related to age or sex. Volume of distribution (corrected for weight) was larger in men than in women (0.99 and 0.86 llkg) and declined with age in both sexes. This probably reflects increased fat per kilogram body weight in women and in the elderly, together with incomplete distribution of this nonlipophilic drug into body fat. Acetaminophen clearance tended to decline with age in both sexes, but differences were of borderline significance. On the basis of kinetic data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume31
Issue number2
StatePublished - Feb 1982
Externally publishedYes

Fingerprint

Acetaminophen
Sex Characteristics
Half-Life
Adipose Tissue
Research Design
Pharmacokinetics
Fats
Body Weight
Weights and Measures
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Divoll, M., Abernethy, D. R., Ameer, B., & Greenblatt, D. J. (1982). Acetaminophen kinetics in the elderly. Clinical Pharmacology and Therapeutics, 31(2), 151-156.

Acetaminophen kinetics in the elderly. / Divoll, Marcia; Abernethy, Darrell R.; Ameer, Barbara; Greenblatt, David J.

In: Clinical Pharmacology and Therapeutics, Vol. 31, No. 2, 02.1982, p. 151-156.

Research output: Contribution to journalArticle

Divoll, M, Abernethy, DR, Ameer, B & Greenblatt, DJ 1982, 'Acetaminophen kinetics in the elderly', Clinical Pharmacology and Therapeutics, vol. 31, no. 2, pp. 151-156.
Divoll M, Abernethy DR, Ameer B, Greenblatt DJ. Acetaminophen kinetics in the elderly. Clinical Pharmacology and Therapeutics. 1982 Feb;31(2):151-156.
Divoll, Marcia ; Abernethy, Darrell R. ; Ameer, Barbara ; Greenblatt, David J. / Acetaminophen kinetics in the elderly. In: Clinical Pharmacology and Therapeutics. 1982 ; Vol. 31, No. 2. pp. 151-156.
@article{2e39fd2a70a7429a98afe7a5cd4119e3,
title = "Acetaminophen kinetics in the elderly",
abstract = "Thirty-two healthy men and women, 23 to 78 yr old, received single 650-mg intravenous doses of acetaminophen and the drug's kinetics were determined from multiple plasma samples drawn over the next 8 to 12 hr. Acetaminophen elimination half-life averaged 2.7 hr (range, 1.9 to 4.3 hr) and was not related to age or sex. Volume of distribution (corrected for weight) was larger in men than in women (0.99 and 0.86 llkg) and declined with age in both sexes. This probably reflects increased fat per kilogram body weight in women and in the elderly, together with incomplete distribution of this nonlipophilic drug into body fat. Acetaminophen clearance tended to decline with age in both sexes, but differences were of borderline significance. On the basis of kinetic data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary.",
author = "Marcia Divoll and Abernethy, {Darrell R.} and Barbara Ameer and Greenblatt, {David J.}",
year = "1982",
month = "2",
language = "English (US)",
volume = "31",
pages = "151--156",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Acetaminophen kinetics in the elderly

AU - Divoll, Marcia

AU - Abernethy, Darrell R.

AU - Ameer, Barbara

AU - Greenblatt, David J.

PY - 1982/2

Y1 - 1982/2

N2 - Thirty-two healthy men and women, 23 to 78 yr old, received single 650-mg intravenous doses of acetaminophen and the drug's kinetics were determined from multiple plasma samples drawn over the next 8 to 12 hr. Acetaminophen elimination half-life averaged 2.7 hr (range, 1.9 to 4.3 hr) and was not related to age or sex. Volume of distribution (corrected for weight) was larger in men than in women (0.99 and 0.86 llkg) and declined with age in both sexes. This probably reflects increased fat per kilogram body weight in women and in the elderly, together with incomplete distribution of this nonlipophilic drug into body fat. Acetaminophen clearance tended to decline with age in both sexes, but differences were of borderline significance. On the basis of kinetic data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary.

AB - Thirty-two healthy men and women, 23 to 78 yr old, received single 650-mg intravenous doses of acetaminophen and the drug's kinetics were determined from multiple plasma samples drawn over the next 8 to 12 hr. Acetaminophen elimination half-life averaged 2.7 hr (range, 1.9 to 4.3 hr) and was not related to age or sex. Volume of distribution (corrected for weight) was larger in men than in women (0.99 and 0.86 llkg) and declined with age in both sexes. This probably reflects increased fat per kilogram body weight in women and in the elderly, together with incomplete distribution of this nonlipophilic drug into body fat. Acetaminophen clearance tended to decline with age in both sexes, but differences were of borderline significance. On the basis of kinetic data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary.

UR - http://www.scopus.com/inward/record.url?scp=0020048862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020048862&partnerID=8YFLogxK

M3 - Article

C2 - 7056022

AN - SCOPUS:0020048862

VL - 31

SP - 151

EP - 156

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 2

ER -