Abstract
Thirty-two healthy men and women, 23 to 78 yr old, received single 650-mg intravenous doses of acetaminophen and the drug's kinetics were determined from multiple plasma samples drawn over the next 8 to 12 hr. Acetaminophen elimination half-life averaged 2.7 hr (range, 1.9 to 4.3 hr) and was not related to age or sex. Volume of distribution (corrected for weight) was larger in men than in women (0.99 and 0.86 llkg) and declined with age in both sexes. This probably reflects increased fat per kilogram body weight in women and in the elderly, together with incomplete distribution of this nonlipophilic drug into body fat. Acetaminophen clearance tended to decline with age in both sexes, but differences were of borderline significance. On the basis of kinetic data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 151-156 |
| Number of pages | 6 |
| Journal | Clinical Pharmacology and Therapeutics |
| Volume | 31 |
| Issue number | 2 |
| State | Published - Feb 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Acetaminophen kinetics in the elderly. / Divoll, Marcia; Abernethy, Darrell R.; Ameer, Barbara; Greenblatt, David J.
In: Clinical Pharmacology and Therapeutics, Vol. 31, No. 2, 02.1982, p. 151-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acetaminophen kinetics in the elderly
AU - Divoll, Marcia
AU - Abernethy, Darrell R.
AU - Ameer, Barbara
AU - Greenblatt, David J.
PY - 1982/2
Y1 - 1982/2
N2 - Thirty-two healthy men and women, 23 to 78 yr old, received single 650-mg intravenous doses of acetaminophen and the drug's kinetics were determined from multiple plasma samples drawn over the next 8 to 12 hr. Acetaminophen elimination half-life averaged 2.7 hr (range, 1.9 to 4.3 hr) and was not related to age or sex. Volume of distribution (corrected for weight) was larger in men than in women (0.99 and 0.86 llkg) and declined with age in both sexes. This probably reflects increased fat per kilogram body weight in women and in the elderly, together with incomplete distribution of this nonlipophilic drug into body fat. Acetaminophen clearance tended to decline with age in both sexes, but differences were of borderline significance. On the basis of kinetic data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary.
AB - Thirty-two healthy men and women, 23 to 78 yr old, received single 650-mg intravenous doses of acetaminophen and the drug's kinetics were determined from multiple plasma samples drawn over the next 8 to 12 hr. Acetaminophen elimination half-life averaged 2.7 hr (range, 1.9 to 4.3 hr) and was not related to age or sex. Volume of distribution (corrected for weight) was larger in men than in women (0.99 and 0.86 llkg) and declined with age in both sexes. This probably reflects increased fat per kilogram body weight in women and in the elderly, together with incomplete distribution of this nonlipophilic drug into body fat. Acetaminophen clearance tended to decline with age in both sexes, but differences were of borderline significance. On the basis of kinetic data alone, adjustment of acetaminophen dosage for the elderly is generally not necessary.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020048862&partnerID=8YFLogxK
M3 - Article
C2 - 7056022
AN - SCOPUS:0020048862
VL - 31
SP - 151
EP - 156
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 2
ER -