@article{1cc557657f4148f9af05de7336ede05d,
title = "ACE2 mouse models: a toolbox for cardiovascular and pulmonary research",
abstract = "Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. ACE2 is a regulatory enzyme of the renin-angiotensin system and has protective functions in many cardiovascular, pulmonary and metabolic diseases. This review summarizes available murine models with systemic or organ-specific deletion of ACE2, or with overexpression of murine or human ACE2. The purpose of this review is to provide researchers with the genetic tools available for further understanding of ACE2 biology and for the investigation of ACE2 in the pathogenesis and treatment of COVID-19.",
author = "Hongpeng Jia and Xinping Yue and Eric Lazartigues",
note = "Funding Information: MMRRC Mutant Mouse Resources & Research Centers supported by NIH, NRCMM/MARC National Resource Center of Model Mice/Model Animal Research Center of Nanjing University, China. Funding Information: MMRRC Mutant Mouse Resources & Research Centers supported by NIH, NRCMM/MARC National Resource Center of Model Mice/Model Animal Research Center of Nanjing University, China. Bold numbers refer to the various models in the order listed in the text. Funding Information: These authors thank Dr. Jiaxi Xu (Xi{\textquoteright}an Jiaotong University, PR China) for helping identify some of the models. This work was supported in part by research grants from the National Institutes of Health (AI149321 and AI148446 to H.J., COBRE P30GM106392, HL150592, and HL135635 to E.L. and X.Y.), and the Department of Veterans Affairs (BX004294 to E.L.). Publisher Copyright: {\textcopyright} 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41467-020-18880-0",
language = "English (US)",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}