Accurate high-resolution measurements of 3-D tissue dynamics with registration-enhanced displacement encoded MRI

Arnold Gomez, Samer S. Merchant, Edward W. Hsu

Research output: Contribution to journalArticle


Displacement fields are important to analyze deformation, which is associated with functional and material tissue properties often used as indicators of health. Magnetic resonance imaging (MRI) techniques like DENSE and image registration methods like Hyperelastic Warping have been used to produce pixel-level deformation fields that are desirable in high-resolution analysis. However, DENSE can be complicated by challenges associated with image phase unwrapping, in particular offset determination. On the other hand, Hyperelastic Warping can be hampered by low local image contrast. The current work proposes a novel approach for measuring tissue displacement with both DENSE and Hyperelastic Warping, incorporating physically accurate displacements obtained by the latter to improve phase characterization in DENSE. The validity of the proposed technique is demonstrated using numerical and physical phantoms, and in vivo small animal cardiac MRI.

Original languageEnglish (US)
Article number6767030
Pages (from-to)1350-1362
Number of pages13
JournalIEEE transactions on medical imaging
Issue number6
Publication statusPublished - Jan 1 2014
Externally publishedYes



  • Cardiac deformation
  • Cardiac imaging
  • Magnetic resonance displacement encoding
  • Magnetic resonance imaging (MRI)
  • Weighted phase imaging

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

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