Accuracy of hemodynamic measurements during partial liquid ventilation with perflubron

Research output: Contribution to journalArticlepeer-review

Abstract

Patients undergoing partial liquid ventilation (PLV) are often monitored with pulmonary artery catheters and receive positive endexpiratory pressure (PEEP). PEEP can dissociate wedge pressure (Pcw) from transmural left atrial pressure (Platm) by elevating pleural pressure and can dissociate Pcw from Pla by elevating alveolar pressure, PLV, like PEEP, also elevates pleural and alveolar pressures. However, the artifacts PLV may cause in measured vascular pressures are unknown. In 6 anesthetized, paralyzed healthy adult sheep, we compared effects of gas ventilation (GV) and PLV with 10 and 30 ml/kg perflubron on pericardial pressure (Pperi), Pcw, Pla, thermodilution cardiac output, and pulmonary artery flow measured with a doppler probe. PEEP was applied from 0-15 mm Hg during GV and PLV. PLV changed pericardial pressure or cardiac output minimally (at PEEP0, GV: Pperi = -1.7 ± 0.6 mm Hg, CO = 3.2 ± 0.1 L/m; 10 ml/kg perflubron: Pperi = -1.3 ± 0.6 mm Hg, CO = 3.4 ± 0.2 L/m; 30 ml/kg perflubron: Pperi = -1.6 ± 0.7 mm Hg, CO = 3.4 ± 0.2 L/m; all mean ± SEM). On PEEP, Pcw agreed with Pla and Platm as well or better during PLV as during gas ventilation. Cardiac output by thermodilutlon and probe agreed equally well under all conditions. We conclude that hemodynamic values are as accurate during PLV as during gas ventilation.

Original languageEnglish (US)
Pages (from-to)1372-1376
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Volume162
Issue number4 I
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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