Accuracy of creatinine clearance in measuring glomerular filtration rate in patients with systemic lupus erythematosus without clinical evidence of renal disease

Jill S. Ratain; Michelle Petri; Marc C. Hochberg; David B. Hellmann

doi:10.1002/art.1780330219

Accuracy of creatinine clearance in measuring glomerular filtration rate in patients with systemic lupus erythematosus without clinical evidence of renal disease

Jill S. Ratain, Michelle Petri, Marc C. Hochberg, David B. Hellmann

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We sought to determine whether creatinine clearance (C_cr) gives an accurate measurement of the glomerular filtration rate in patients with systemic lupus erythematosus (SLE) with no clinical evidence of renal disease. Eighteen such SLE patients underwent measurement of C_cr and ^99mtechnetium‐DTPA clearance (C_DTPA). The mean ± SD C_cr:C_DTPA ratio was 1.12 ± 0.15 (95% confidence interval 1.04–1.20). These results indicate that C_cr gives an accurate measurement of the glomerular filtration rate in the majority of SLE patients who do not have clinical evidence of renal disease.

Original language	English (US)
Pages (from-to)	277-280
Number of pages	4
Journal	Arthritis & Rheumatism
Volume	33
Issue number	2
DOIs	https://doi.org/10.1002/art.1780330219
State	Published - Feb 1990

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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abstract = "We sought to determine whether creatinine clearance (Ccr) gives an accurate measurement of the glomerular filtration rate in patients with systemic lupus erythematosus (SLE) with no clinical evidence of renal disease. Eighteen such SLE patients underwent measurement of Ccr and 99mtechnetium‐DTPA clearance (CDTPA). The mean ± SD Ccr:CDTPA ratio was 1.12 ± 0.15 (95% confidence interval 1.04–1.20). These results indicate that Ccr gives an accurate measurement of the glomerular filtration rate in the majority of SLE patients who do not have clinical evidence of renal disease.",

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AB - We sought to determine whether creatinine clearance (Ccr) gives an accurate measurement of the glomerular filtration rate in patients with systemic lupus erythematosus (SLE) with no clinical evidence of renal disease. Eighteen such SLE patients underwent measurement of Ccr and 99mtechnetium‐DTPA clearance (CDTPA). The mean ± SD Ccr:CDTPA ratio was 1.12 ± 0.15 (95% confidence interval 1.04–1.20). These results indicate that Ccr gives an accurate measurement of the glomerular filtration rate in the majority of SLE patients who do not have clinical evidence of renal disease.

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Accuracy of creatinine clearance in measuring glomerular filtration rate in patients with systemic lupus erythematosus without clinical evidence of renal disease

Abstract

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