Accuracy of creatinine clearance in measuring glomerular filtration rate in patients with systemic lupus erythematosus without clinical evidence of renal disease

Jill S. Ratain, Michelle Petri, Marc C. Hochberg, David B Hellmann

Research output: Contribution to journalArticle

Abstract

We sought to determine whether creatinine clearance (Ccr) gives an accurate measurement of the glomerular filtration rate in patients with systemic lupus erythematosus (SLE) with no clinical evidence of renal disease. Eighteen such SLE patients underwent measurement of Ccr and 99mtechnetium-DTPA clearance (CDTPA). The mean ± SD Ccr:CDTPA ratio was 1.12 ± 0.15 (95% confidence interval 1.04-1.20). These results indicate that Ccr gives an accurate measurement of the glomerular filtration rate in the majority of SLE patients who do not have clinical evidence of renal disease.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalArthritis and Rheumatism
Volume33
Issue number2
StatePublished - Feb 1990

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Glomerular Filtration Rate
Systemic Lupus Erythematosus
Creatinine
Kidney
Pentetic Acid
Confidence Intervals

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

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abstract = "We sought to determine whether creatinine clearance (Ccr) gives an accurate measurement of the glomerular filtration rate in patients with systemic lupus erythematosus (SLE) with no clinical evidence of renal disease. Eighteen such SLE patients underwent measurement of Ccr and 99mtechnetium-DTPA clearance (CDTPA). The mean ± SD Ccr:CDTPA ratio was 1.12 ± 0.15 (95{\%} confidence interval 1.04-1.20). These results indicate that Ccr gives an accurate measurement of the glomerular filtration rate in the majority of SLE patients who do not have clinical evidence of renal disease.",
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