Accuracy of contrast-enhanced breast ultrasound for pre-operative tumor size assessment in patients diagnosed with invassive ductal carcinoma of the breast

S. van Esser, W. B. Veldhuis, R. van Hillegersberg, P. J. van Diest, G. Stapper, M. El Ouamari, I. H M Borel Rinkes, W. P Th M Mali, M. A A J van den Bosch

Research output: Contribution to journalArticle

Abstract

Our aim was to assess the feasibility and accuracy of contrast-enhanced ultrasound (CEUS) of the breast with SonoVue microbubbles for pre-operative size measurement of invasive breast carcinomas. Seven patients diagnosed with nine invasive breast carcinomas prospectively underwent gray-scale ultrasound and CEUS of the breast according to a standardized protocol. CEUS of the breast was performed by a Philips iU22 scanner equipped with a 4-8 MHz linear array transducer. We used a single dose of 2.4ml SonoVue as contrast agent. Breast lesion morphology was scored according to the sonographic BI-RADS lexicon criteria and classified accordingly. The greatest tumor dimensions on gray-scale ultrasound and CEUS of the breast were finally compared with the greatest histopathologic tumor sizes. Gray-scale ultrasound underestimated the histopathologic tumor size in 6/9 cases (67%), whereas CEUS of the breast underestimated tumor size in only 319 (33%) cases. CEUS of the breast was significantly more accurate for tumor size assessment. Greatest tumor dimension as measured with gray-scale ultrasound of the breast was within 2 mm of the pathologic tumor size in only 2/9 cases (22%), whereas CEUS of the breast accurately assessed tumor size within 2mm of pathologic tumor size in 6/9 (67%) of the cases (P

Original languageEnglish (US)
Pages (from-to)63-68
Number of pages6
JournalCancer Imaging
Volume7
Issue number1
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Accuracy
  • Breast cancer
  • Contrast-enhanced ultrasound
  • SonoVue
  • Tumor size

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

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    van Esser, S., Veldhuis, W. B., van Hillegersberg, R., van Diest, P. J., Stapper, G., El Ouamari, M., Borel Rinkes, I. H. M., Mali, W. P. T. M., & van den Bosch, M. A. A. J. (2007). Accuracy of contrast-enhanced breast ultrasound for pre-operative tumor size assessment in patients diagnosed with invassive ductal carcinoma of the breast. Cancer Imaging, 7(1), 63-68. https://doi.org/10.1102/1470-7330.2007.0012