Accuracy of Computed Tomographic Angiography and Single-Photon Emission Computed Tomography-Acquired Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease

Armin Zadeh, Marcelo F Di Carli, Rodrigo Cerci, Richard T. George, Marcus Y. Chen, Marc Dewey, Hiroyuki Niinuma, Andrea L. Vavere, Aisha Betoko, Michail Plotkin, Christopher Cox, Melvin E. Clouse, Andrew E. Arai, Carlos E. Rochitte, Joao Lima, Jeffrey A Brinker, Julie M Miller

Research output: Contribution to journalArticle

Abstract

Establishing the diagnosis of coronary artery disease (CAD) in symptomatic patients allows appropriately allocating preventative measures. Single-photon emission computed tomography (CT)-acquired myocardial perfusion imaging (SPECT-MPI) is frequently used for the evaluation of CAD, but coronary CT angiography (CTA) has emerged as a valid alternative. Methods and Results-We compared the accuracy of SPECT-MPI and CTA for the diagnosis of CAD in 391 symptomatic patients who were prospectively enrolled in a multicenter study after clinical referral for cardiac catheterization. The area under the receiver operating characteristic curve was used to evaluate the diagnostic accuracy of CTA and SPECT-MPI for identifying patients with CAD defined as the presence of ≥1 coronary artery with ≥50% lumen stenosis by quantitative coronary angiography. Sensitivity to identify patients with CAD was greater for CTA than SPECT-MPI (0.92 versus 0.62, respectively; P

Original languageEnglish (US)
Article numbere003533
JournalCirculation: Cardiovascular Imaging
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2015

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Myocardial Perfusion Imaging
Single-Photon Emission-Computed Tomography
Coronary Artery Disease
Angiography
Cardiac Catheterization
Coronary Angiography
ROC Curve
Multicenter Studies
Coronary Vessels
Pathologic Constriction
Referral and Consultation
Computed Tomography Angiography

Keywords

  • Coronary angiography
  • coronary artery disease
  • myocardial ischemia
  • myocardial perfusion imaging
  • ROC curve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Accuracy of Computed Tomographic Angiography and Single-Photon Emission Computed Tomography-Acquired Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease. / Zadeh, Armin; Carli, Marcelo F Di; Cerci, Rodrigo; George, Richard T.; Chen, Marcus Y.; Dewey, Marc; Niinuma, Hiroyuki; Vavere, Andrea L.; Betoko, Aisha; Plotkin, Michail; Cox, Christopher; Clouse, Melvin E.; Arai, Andrew E.; Rochitte, Carlos E.; Lima, Joao; Brinker, Jeffrey A; Miller, Julie M.

In: Circulation: Cardiovascular Imaging, Vol. 8, No. 10, e003533, 01.10.2015.

Research output: Contribution to journalArticle

Zadeh, Armin ; Carli, Marcelo F Di ; Cerci, Rodrigo ; George, Richard T. ; Chen, Marcus Y. ; Dewey, Marc ; Niinuma, Hiroyuki ; Vavere, Andrea L. ; Betoko, Aisha ; Plotkin, Michail ; Cox, Christopher ; Clouse, Melvin E. ; Arai, Andrew E. ; Rochitte, Carlos E. ; Lima, Joao ; Brinker, Jeffrey A ; Miller, Julie M. / Accuracy of Computed Tomographic Angiography and Single-Photon Emission Computed Tomography-Acquired Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease. In: Circulation: Cardiovascular Imaging. 2015 ; Vol. 8, No. 10.
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