Accuracy and response time of dual biomarker model of insulin-like growth factor binding protein-1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha-microglobulin-1 test in diagnosis of premature rupture of membranes

George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Eke, Joseph Ifeanyichukwu Ikechebelu, Chukwuemeka Okwudili Ezeama, Ifeanyichukwu Uzoma Ezebialu, Nnabuike Okechukwu Ojiegbe, Chukwudi Celestine Obiora, Charles Ikechukwu Okafor, Gerald Okanandu Udigwe, Betrand Obi Nwosu, Frank O. Ezugwu

Research output: Contribution to journalArticle

Abstract

Aim: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). Methods: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM. Response time analysis was also done. Outcome measures included specificity, sensitivity, positive predictive value, negative predictive value, accuracy, and response time for both tests. Results: Sensitivity, specificity, and accuracy for Amnioquick duo+ were 97.9%, 97.6%, and 97.9%, which were higher than the levels for PAMG-1, of 95.3%, 90.0%, and 95.7%, respectively (not significant). Accuracy of Amnioquick duo+ versus PAMG-1 in equivocal (pooling = negative) cases was (98.4% vs 96.8%) at ≥34 GW but each was 100.0% at <34 GW (not significant). Overall diagnostic concordance rate of Amnioquick duo+ and PAMG-1 was 97.0% and both have equal positive predictive value (99.5%). Response time analysis showed that the overall response time of PAMG-1 was 4.5% higher than that of Amnioquick duo+. Conclusion: This is the largest study to date to reveal that Amnioquick duo+ and PAMG-1 have a comparatively high diagnostic accuracy in identifying women with PROM, with a concordance rate of 97.0%. The diagnostic response time of Amnioquick duo+ appears shorter. In equivocal cases, accuracy of Amnioquick duo+ was equal to that of the PAMG-1.

Original languageEnglish (US)
Pages (from-to)825-833
Number of pages9
JournalJournal of Obstetrics and Gynaecology Research
Volume43
Issue number5
DOIs
StatePublished - May 1 2017

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Insulin-Like Growth Factor Binding Protein 1
alpha-Fetoproteins
Reaction Time
Rupture
Biomarkers
Membranes
Chorioamnionitis
Sensitivity and Specificity
alpha-1-microglobulin
Multicenter Studies
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • accuracy
  • Amnioquick duo+
  • placental alpha-microglobulin-1
  • premature rupture of membranes
  • sensitivity
  • specificity

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Accuracy and response time of dual biomarker model of insulin-like growth factor binding protein-1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha-microglobulin-1 test in diagnosis of premature rupture of membranes. / Eleje, George Uchenna; Ezugwu, Euzebus Chinonye; Eke, Ahizechukwu; Ikechebelu, Joseph Ifeanyichukwu; Ezeama, Chukwuemeka Okwudili; Ezebialu, Ifeanyichukwu Uzoma; Ojiegbe, Nnabuike Okechukwu; Obiora, Chukwudi Celestine; Okafor, Charles Ikechukwu; Udigwe, Gerald Okanandu; Nwosu, Betrand Obi; Ezugwu, Frank O.

In: Journal of Obstetrics and Gynaecology Research, Vol. 43, No. 5, 01.05.2017, p. 825-833.

Research output: Contribution to journalArticle

Eleje, George Uchenna ; Ezugwu, Euzebus Chinonye ; Eke, Ahizechukwu ; Ikechebelu, Joseph Ifeanyichukwu ; Ezeama, Chukwuemeka Okwudili ; Ezebialu, Ifeanyichukwu Uzoma ; Ojiegbe, Nnabuike Okechukwu ; Obiora, Chukwudi Celestine ; Okafor, Charles Ikechukwu ; Udigwe, Gerald Okanandu ; Nwosu, Betrand Obi ; Ezugwu, Frank O. / Accuracy and response time of dual biomarker model of insulin-like growth factor binding protein-1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha-microglobulin-1 test in diagnosis of premature rupture of membranes. In: Journal of Obstetrics and Gynaecology Research. 2017 ; Vol. 43, No. 5. pp. 825-833.
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abstract = "Aim: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). Methods: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM. Response time analysis was also done. Outcome measures included specificity, sensitivity, positive predictive value, negative predictive value, accuracy, and response time for both tests. Results: Sensitivity, specificity, and accuracy for Amnioquick duo+ were 97.9{\%}, 97.6{\%}, and 97.9{\%}, which were higher than the levels for PAMG-1, of 95.3{\%}, 90.0{\%}, and 95.7{\%}, respectively (not significant). Accuracy of Amnioquick duo+ versus PAMG-1 in equivocal (pooling = negative) cases was (98.4{\%} vs 96.8{\%}) at ≥34 GW but each was 100.0{\%} at <34 GW (not significant). Overall diagnostic concordance rate of Amnioquick duo+ and PAMG-1 was 97.0{\%} and both have equal positive predictive value (99.5{\%}). Response time analysis showed that the overall response time of PAMG-1 was 4.5{\%} higher than that of Amnioquick duo+. Conclusion: This is the largest study to date to reveal that Amnioquick duo+ and PAMG-1 have a comparatively high diagnostic accuracy in identifying women with PROM, with a concordance rate of 97.0{\%}. The diagnostic response time of Amnioquick duo+ appears shorter. In equivocal cases, accuracy of Amnioquick duo+ was equal to that of the PAMG-1.",
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T1 - Accuracy and response time of dual biomarker model of insulin-like growth factor binding protein-1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha-microglobulin-1 test in diagnosis of premature rupture of membranes

AU - Eleje, George Uchenna

AU - Ezugwu, Euzebus Chinonye

AU - Eke, Ahizechukwu

AU - Ikechebelu, Joseph Ifeanyichukwu

AU - Ezeama, Chukwuemeka Okwudili

AU - Ezebialu, Ifeanyichukwu Uzoma

AU - Ojiegbe, Nnabuike Okechukwu

AU - Obiora, Chukwudi Celestine

AU - Okafor, Charles Ikechukwu

AU - Udigwe, Gerald Okanandu

AU - Nwosu, Betrand Obi

AU - Ezugwu, Frank O.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Aim: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). Methods: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM. Response time analysis was also done. Outcome measures included specificity, sensitivity, positive predictive value, negative predictive value, accuracy, and response time for both tests. Results: Sensitivity, specificity, and accuracy for Amnioquick duo+ were 97.9%, 97.6%, and 97.9%, which were higher than the levels for PAMG-1, of 95.3%, 90.0%, and 95.7%, respectively (not significant). Accuracy of Amnioquick duo+ versus PAMG-1 in equivocal (pooling = negative) cases was (98.4% vs 96.8%) at ≥34 GW but each was 100.0% at <34 GW (not significant). Overall diagnostic concordance rate of Amnioquick duo+ and PAMG-1 was 97.0% and both have equal positive predictive value (99.5%). Response time analysis showed that the overall response time of PAMG-1 was 4.5% higher than that of Amnioquick duo+. Conclusion: This is the largest study to date to reveal that Amnioquick duo+ and PAMG-1 have a comparatively high diagnostic accuracy in identifying women with PROM, with a concordance rate of 97.0%. The diagnostic response time of Amnioquick duo+ appears shorter. In equivocal cases, accuracy of Amnioquick duo+ was equal to that of the PAMG-1.

AB - Aim: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). Methods: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM. Response time analysis was also done. Outcome measures included specificity, sensitivity, positive predictive value, negative predictive value, accuracy, and response time for both tests. Results: Sensitivity, specificity, and accuracy for Amnioquick duo+ were 97.9%, 97.6%, and 97.9%, which were higher than the levels for PAMG-1, of 95.3%, 90.0%, and 95.7%, respectively (not significant). Accuracy of Amnioquick duo+ versus PAMG-1 in equivocal (pooling = negative) cases was (98.4% vs 96.8%) at ≥34 GW but each was 100.0% at <34 GW (not significant). Overall diagnostic concordance rate of Amnioquick duo+ and PAMG-1 was 97.0% and both have equal positive predictive value (99.5%). Response time analysis showed that the overall response time of PAMG-1 was 4.5% higher than that of Amnioquick duo+. Conclusion: This is the largest study to date to reveal that Amnioquick duo+ and PAMG-1 have a comparatively high diagnostic accuracy in identifying women with PROM, with a concordance rate of 97.0%. The diagnostic response time of Amnioquick duo+ appears shorter. In equivocal cases, accuracy of Amnioquick duo+ was equal to that of the PAMG-1.

KW - accuracy

KW - Amnioquick duo+

KW - placental alpha-microglobulin-1

KW - premature rupture of membranes

KW - sensitivity

KW - specificity

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