Accessory function and properties of monocytes from healthy elderly humans for T lymphocyte responses to mitogen and antigen

Elizabeth A. Rich, Maria A. Mincek, Keith B. Annitage, Evelyn G. Duffy, Donna C. Owen, John D. Fayen, David L. Hom, Jerrold J. Ellner

Research output: Contribution to journalArticle

Abstract

The waning of cell-mediated immunity during aging has been attributed primarily to defects in T lymphocyte properties and functions. We assessed the potential contribution of accessory dysfunction of monocytes from the elderly on responses of T cells to phytohemagglutinin (PHA) and to tetanus toxoid after in vivo boosting. Accessory function of monocytes from the elderly subjects for T lymphocyte responses to tetanus toxoid was comparable to the young. Expression of the cytokines interleukin-1. intcrleukin-6 and tumor necrosis factor, the cell adhesion molecules ICAM-1 and LFA-3 and the class II major histocompatibility molecule HLA-DR by monocytes from the elderly and young subjects was similar. T lymphocytes from the elderly responded poorly to PHA. Monocytes from the elderly had a decreased accessory function for PHA-stimu-lated T cells from young, third donors. Thus, although many accessory properties of monocytes from the elderly are normal. the monocyte and T lymphocyte defects in the elderly for mitogen may represent interactive factors in cell-mediated immunity during aging.

Original languageEnglish (US)
Pages (from-to)93-108
Number of pages16
JournalGerontology
Volume39
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Cell adhesion molecules
  • Cytokines
  • Immunoregulation
  • Immunosenescence
  • Mononuclear phagocytes

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Accessory function and properties of monocytes from healthy elderly humans for T lymphocyte responses to mitogen and antigen'. Together they form a unique fingerprint.

  • Cite this

    Rich, E. A., Mincek, M. A., Annitage, K. B., Duffy, E. G., Owen, D. C., Fayen, J. D., Hom, D. L., & Ellner, J. J. (1993). Accessory function and properties of monocytes from healthy elderly humans for T lymphocyte responses to mitogen and antigen. Gerontology, 39(2), 93-108. https://doi.org/10.1159/000213519