@article{7e7e691e773d4ed2a333912792dcf3a2,
title = "Acceptability of a Dapivirine/Placebo Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-026)",
abstract = "This study describes the acceptability of a rectal microbicide gel formulation using dapivirine (DPV) among men and women from two countries (United States and Thailand) participating in the Microbicide Trials Network-026 trial. We evaluated participants{\textquoteright} acceptability of a rectal DPV/placebo gel as part of a Phase I trial (N = 26; 18 male, 8 female). Participants reported favorable acceptability of the study gel, with most participants reporting that they liked the gel the same (n = 14; 53.8%) or more (n = 11; 42.4%) than when they started the trial. Over half of participants noted that they would prefer the gel over condoms (n = 13; 50%) or that they liked condoms and the gel equally (n = 8; 30.8%). Side effects across products included leakage (n = 8; 30.8%), diarrhea (n = 4; 15.4%), or soiling (n = 1; 3.8%). The high acceptability of a rectal gel underscores its promise as a short-acting biomedical prevention, warranting future research for HIV prevention. Trial Registration: NCT03239483.",
keywords = "Dapivirine, HIV, HIV prevention, Microbicides, Rectal",
author = "{the MTN 026 team} and Bauermeister, {Jos{\'e} A.} and Tingler, {Ryan C.} and Clara Dominguez and Dunne, {Eileen F.} and Craig Hoesley and Ken Ho and Sherri Johnson and Jonathan Lucas and Nicole Macagna and Elizabeth Brown and Holly Gundacker and Melissa Peda and Jacobson, {Cindy E.} and Lindsay Kramzer and Devika Singh and Dezzutti, {Charlene S.} and Ayudhya, {Ratiya Pamela Kunjara Na} and Marzinke, {Mark A.} and Jeanna Piper and Br{\'i}d Devlin and Jeremy Nuttall and Ian McGowan and Hendrix, {Craig W.} and Cranston, {Ross D.}",
note = "Funding Information: The study was designed and implemented by the Microbicide Trials Network (MTN). The MTN is funded by the National Institute of Allergy and Infectious Diseases (UM1AI068633, UM1AI068615, UM1AI106707), with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institute of Mental Health, all components of the U.S. National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the official positions of the U.S. Centers for Disease Control and Prevention. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
doi = "10.1007/s10461-021-03490-8",
language = "English (US)",
journal = "AIDS and Behavior",
issn = "1090-7165",
publisher = "Springer New York",
}