Acceleration of small bowel transit in a canine hypermotility model with intestinal electrical stimulation

Wei Feng Wang, Jie Yun Yin, Jian De Dz Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Few studies have been performed on the effect of intestinal electrical stimulation (IES) on intestinal dysmotility. This study aimed to investigate the small intestine transit (SIT) in a canine model of intestinal hypermotility when applying IES. Method: Six hound bitches were surgically prepared with two chronic intestinal fistulas, intestinal serosal electrodes of which the proximal pair was used for serosal IES. Pacing wires were attached to a manometric catheter for mucosal IES. A nitrogen oxide synthase inhibitor, Nω-nitro-L-arginine (LNNA) was used to induce intestinal motility. SIT was measured during IES. The study consisted of four randomized sessions: session 1 (LNNA), session 2 (LNNA plus serosal IES), session 3 (LNNA plus mucosal IES) and session 4 (control). Results: The intestine transit was slowed down from 31.7±6.1min in the control session to 49.0±6.2min after using LNNA (P=0.003). Both mucosal and serosal IES accelerated SIT compared with the LNNA session. The SIT time was reduced to 17.7±3.4min in the mucosal IES session (P=0.006 vs LNNA) and 27.5±6.3min in the serosal IES session (P=0.020 vs LNNA). No difference was noted in the SIT time between mucosal and serosal IES (P=0.128). Conclusion: IES significantly accelerates delayed SIT in a hypermotility model and intraluminal stimulation is as effective as a serosal one for IES, suggesting that IES may have a therapeutic potential for improving intestinal motility.

Original languageEnglish (US)
Pages (from-to)135-142
Number of pages8
JournalJournal of Digestive Diseases
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Hypermotility
  • Intestinal electrical stimulation
  • Small intestine transit

ASJC Scopus subject areas

  • Gastroenterology

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