Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology

Anne B. Newman; Stephen B. Kritchevsky; Jack M. Guralnik; Steven R. Cummings; Marcel Salive; George A. Kuchel; Jennifer Schrack; Martha Clare Morris; David Weir; Andrea Baccarelli; Joanne M. Murabito; Yoav Ben-Shlomo; Mark A. Espeland; James Kirkland; David Melzer; Luigi Ferrucci

doi:10.1093/gerona/glz230

Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology

Anne B. Newman, Stephen B. Kritchevsky, Jack M. Guralnik, Steven R. Cummings, Marcel Salive, George A. Kuchel, Jennifer Schrack, Martha Clare Morris, David Weir, Andrea Baccarelli, Joanne M. Murabito, Yoav Ben-Shlomo, Mark A. Espeland, James Kirkland, David Melzer, Luigi Ferrucci

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Background: Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. Methods: Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. Results: Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. Conclusions: Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.

Original language	English (US)
Pages (from-to)	77-86
Number of pages	10
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	75
Issue number	1
DOIs	https://doi.org/10.1093/gerona/glz230
State	Published - Jan 1 2020

Keywords

Epidemiology
Longevity
Successful aging

ASJC Scopus subject areas

General Medicine

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10.1093/gerona/glz230

Cite this

Newman, A. B., Kritchevsky, S. B., Guralnik, J. M., Cummings, S. R., Salive, M., Kuchel, G. A., Schrack, J., Morris, M. C., Weir, D., Baccarelli, A., Murabito, J. M., Ben-Shlomo, Y., Espeland, M. A., Kirkland, J., Melzer, D., & Ferrucci, L. (2020). Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 75(1), 77-86. https://doi.org/10.1093/gerona/glz230

Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology. / Newman, Anne B.; Kritchevsky, Stephen B.; Guralnik, Jack M. et al.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 75, No. 1, 01.01.2020, p. 77-86.

Research output: Contribution to journal › Review article › peer-review

Newman, AB, Kritchevsky, SB, Guralnik, JM, Cummings, SR, Salive, M, Kuchel, GA, Schrack, J, Morris, MC, Weir, D, Baccarelli, A, Murabito, JM, Ben-Shlomo, Y, Espeland, MA, Kirkland, J, Melzer, D & Ferrucci, L 2020, 'Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 75, no. 1, pp. 77-86. https://doi.org/10.1093/gerona/glz230

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abstract = "Background: Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. Methods: Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. Results: Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. Conclusions: Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.",

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AU - Salive, Marcel

AU - Kuchel, George A.

AU - Schrack, Jennifer

AU - Morris, Martha Clare

AU - Weir, David

AU - Baccarelli, Andrea

AU - Murabito, Joanne M.

AU - Ben-Shlomo, Yoav

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AU - Ferrucci, Luigi

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AB - Background: Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. Methods: Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. Results: Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. Conclusions: Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.

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Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology

Abstract

Keywords

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