@article{3522a9555d05461b962fd5edb697ccfb,
title = "Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology",
abstract = "Background: Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. Methods: Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. Results: Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. Conclusions: Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.",
keywords = "Epidemiology, Longevity, Successful aging",
author = "Newman, {Anne B.} and Kritchevsky, {Stephen B.} and Guralnik, {Jack M.} and Cummings, {Steven R.} and Marcel Salive and Kuchel, {George A.} and Jennifer Schrack and Morris, {Martha Clare} and David Weir and Andrea Baccarelli and Murabito, {Joanne M.} and Yoav Ben-Shlomo and Espeland, {Mark A.} and James Kirkland and David Melzer and Luigi Ferrucci",
note = "Funding Information: A. B. Newman was supported by National Institute on Aging grants R01 AG059416, U01 AG023744, R01 AG059729, P30 AG024827, U01 DK057002, R01 AG052964, UH2 AG056933, U01 HL130114, and 1U19AG062682. L. Ferrucci and M. Salive were supported by the National Institute on Aging. S. R. Cummings was supported by the National Institute on Aging grant AG023122. G. A. Kuchel received National Institutes of Health funding grants R01 AG048023, R01 AG052608, R35 GM124922, UH2 AG056925, R21 AG060018, and R01 AI142086. J. Schrack was supported by National Institutes of Health grants U01 AG057545 and R21 AG053198. A. Baccarelli was supported by National Institute on Aging grants P30 ES009089 and R01 ES025225. J. M.Murabito was supported by National Institute on Aging grants U01AG023755 and U24AG051129. M. A. Espeland was supported by National Institutes of Health grants DK0 92237-01 and DK0 92237-02S2, while research he reported was also funded by two diversity supplements (3U01 DK057136-19S1 and 3U01 DK057136-19S2) to the parent award National Institute of Diabetes and Digestive and Kidney Diseases 5U01 DK057136-19 and the National Institute on Aging Wake Forest Alzheimer{\textquoteright}s Disease Core Center (P30 AG049638-01A1). J. Kirkland was supported by National Institutes of Health grants AG013925, AG062413, and the National Institute on Aging Translational Geroscience Network (AG061456), Robert and Arlene Kogod, the Connor Group, Robert J. and Theresa W. Ryan, and the Ted Nash Long Life and Noaber Foundations. D. Melzer was supported in part by the United Kingdom Medical Research Council (MR/M023095). S. B. Kritchevsky was supported by the National Institute on Aging Wake Forest Older Americans Independence Center (P30 AG021332). Publisher Copyright: {\textcopyright} The Author(s) 2018.",
year = "2020",
month = jan,
day = "1",
doi = "10.1093/gerona/glz230",
language = "English (US)",
volume = "75",
pages = "77--86",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "1",
}