Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

Lintao Qu; Michael J. Caterina

doi:10.1172/JCI122203

Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

Lintao Qu, Michael J. Caterina

School of Medicine

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.

Original language	English (US)
Pages (from-to)	3246-3249
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	128
Issue number	8
DOIs	https://doi.org/10.1172/JCI122203
State	Published - Aug 1 2018

ASJC Scopus subject areas

General Medicine

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10.1172/JCI122203

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title = "Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37",

abstract = "Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.",

author = "Lintao Qu and Caterina, {Michael J.}",

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N2 - Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.

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Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

Abstract

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