Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

Research output: Contribution to journalReview article

Abstract

Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.

Original languageEnglish (US)
Pages (from-to)3246-3249
Number of pages4
JournalJournal of Clinical Investigation
Volume128
Issue number8
DOIs
StatePublished - Aug 1 2018

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Macrophage Activation
G-Protein-Coupled Receptors
Phagocytosis
Anti-Inflammatory Agents
Cytokines
Inflammation
Pain
protectin D1

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37. / Qu, Lintao; Caterina, Michael.

In: Journal of Clinical Investigation, Vol. 128, No. 8, 01.08.2018, p. 3246-3249.

Research output: Contribution to journalReview article

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