TY - JOUR
T1 - Accelerating the development of 21st-century toxicology
T2 - Outcome of a human toxicology project consortium workshop
AU - Stephens, Martin L.
AU - Barrow, Craig
AU - Andersen, Melvin E.
AU - Boekelheide, Kim
AU - Carmichael, Paul L.
AU - Holsapple, Michael P.
AU - Lafranconi, Mark
PY - 2012/2
Y1 - 2012/2
N2 - The U.S. National Research Council (NRC) report on "Toxicity Testing in the 21st century" calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a highthroughput context. The in vitro methods would be designed to detect significant perturbations to "toxicity pathways," i.e., key biological pathways that, when sufficiently perturbed, lead to adverse health outcomes. To explore progress on the report's implementation, the Human Toxicology Project Consortium hosted a workshop on 9-10 November 2010 in Washington, DC. The Consortium is a coalition of several corporations, a research institute, and a non-governmental organization dedicated to accelerating the implementation of 21st-century Toxicology as aligned with the NRC vision. The goal of the workshop was to identify practical and scientific ways to accelerate implementation of the NRC vision. The workshop format consisted of plenary presentations, breakout group discussions, and concluding commentaries. The program faculty was drawn from industry, academia, government, and public interest organizations. Most presentations summarized ongoing efforts to modernize toxicology testing and approaches, each with some overlap with the NRC vision. In light of these efforts, the workshop identified recommendations for accelerating implementation of the NRC vision, including greater strategic coordination and planning across projects (facilitated by a steering group), the development of projects that test the proof of concept for implementation of the NRC vision, and greater outreach and communication across stakeholder communities.
AB - The U.S. National Research Council (NRC) report on "Toxicity Testing in the 21st century" calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a highthroughput context. The in vitro methods would be designed to detect significant perturbations to "toxicity pathways," i.e., key biological pathways that, when sufficiently perturbed, lead to adverse health outcomes. To explore progress on the report's implementation, the Human Toxicology Project Consortium hosted a workshop on 9-10 November 2010 in Washington, DC. The Consortium is a coalition of several corporations, a research institute, and a non-governmental organization dedicated to accelerating the implementation of 21st-century Toxicology as aligned with the NRC vision. The goal of the workshop was to identify practical and scientific ways to accelerate implementation of the NRC vision. The workshop format consisted of plenary presentations, breakout group discussions, and concluding commentaries. The program faculty was drawn from industry, academia, government, and public interest organizations. Most presentations summarized ongoing efforts to modernize toxicology testing and approaches, each with some overlap with the NRC vision. In light of these efforts, the workshop identified recommendations for accelerating implementation of the NRC vision, including greater strategic coordination and planning across projects (facilitated by a steering group), the development of projects that test the proof of concept for implementation of the NRC vision, and greater outreach and communication across stakeholder communities.
KW - In vitro alternatives
KW - National Research Council
KW - Safety assessment
KW - Toxicity testing in the 21st century
UR - http://www.scopus.com/inward/record.url?scp=84856079509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856079509&partnerID=8YFLogxK
U2 - 10.1093/toxsci/kfr248
DO - 10.1093/toxsci/kfr248
M3 - Article
C2 - 21948868
AN - SCOPUS:84856079509
SN - 1096-6080
VL - 125
SP - 327
EP - 334
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 2
ER -