Accelerating aging research: How can we measure the rate of biologic aging?

Joseph Bernard Margolick, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.

Original languageEnglish (US)
Pages (from-to)78-80
Number of pages3
JournalExperimental Gerontology
Volume64
DOIs
StatePublished - Apr 1 2015

Fingerprint

Aging of materials
Phenotype
Research
Premature Aging
Chronic Disease

Keywords

  • Accelerated aging
  • Age-associated diseases
  • Aging phenotype
  • Gerosciences

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Accelerating aging research : How can we measure the rate of biologic aging? / Margolick, Joseph Bernard; Ferrucci, Luigi.

In: Experimental Gerontology, Vol. 64, 01.04.2015, p. 78-80.

Research output: Contribution to journalArticle

@article{54d0c367ef07496cb3046c96dc81b659,
title = "Accelerating aging research: How can we measure the rate of biologic aging?",
abstract = "Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.",
keywords = "Accelerated aging, Age-associated diseases, Aging phenotype, Gerosciences",
author = "Margolick, {Joseph Bernard} and Luigi Ferrucci",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.exger.2015.02.009",
language = "English (US)",
volume = "64",
pages = "78--80",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Accelerating aging research

T2 - How can we measure the rate of biologic aging?

AU - Margolick, Joseph Bernard

AU - Ferrucci, Luigi

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.

AB - Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.

KW - Accelerated aging

KW - Age-associated diseases

KW - Aging phenotype

KW - Gerosciences

UR - http://www.scopus.com/inward/record.url?scp=84923233681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923233681&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2015.02.009

DO - 10.1016/j.exger.2015.02.009

M3 - Article

C2 - 25683017

AN - SCOPUS:84923233681

VL - 64

SP - 78

EP - 80

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -