Abstract
We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of Cimetidine as a cytochrome P450 enzyme inhibitor.
Original language | English (US) |
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Pages (from-to) | 1712-1714 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 53 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases