Accelerated metabolism of voriconazole and its partial reversal by cimetidine

Brad Moriyama, Jason Elinoff, Robert L. Danner, Juan Gea-Banacloche, Gennethel Pennick, Michael G. Rinaldi, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of Cimetidine as a cytochrome P450 enzyme inhibitor.

Original languageEnglish (US)
Pages (from-to)1712-1714
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume53
Issue number4
DOIs
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Moriyama, B., Elinoff, J., Danner, R. L., Gea-Banacloche, J., Pennick, G., Rinaldi, M. G., & Walsh, T. J. (2009). Accelerated metabolism of voriconazole and its partial reversal by cimetidine. Antimicrobial agents and chemotherapy, 53(4), 1712-1714. https://doi.org/10.1128/AAC.01221-08