Accelerated fractional ventilation imaging with hyperpolarized Gas MRI

Kiarash Emami, Yinan Xu, Hooman Hamedani, Harrilla Profka, Stephen Kadlecek, Yi Xin, Masaru Ishii, Rahim R. Rizi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To investigate the utility of accelerated imaging to enhance multibreath fractional ventilation (r) measurement accuracy using hyperpolarized gas MRI. Undersampling shortens the breath-hold time, thereby reducing the O2-induced signal decay and allows subjects to maintain a more physiologically relevant breathing pattern. Additionally, it may improve r estimation accuracy by reducing radiofrequency destruction of hyperpolarized gas. Methods Image acceleration was achieved using an eight-channel phased array coil. Undersampled image acquisition was simulated in a series of ventilation images and data was reconstructed for various matrix sizes (48-128) using generalized auto-calibrating partially parallel acquisition. Parallel accelerated r imaging was also performed on five mechanically ventilated pigs. Results Optimal acceleration factor was fairly invariable (2.0-2.2×) over the range of simulated resolutions. Estimation accuracy progressively improved with higher resolutions (39-51% error reduction). In vivo r values were not significantly different between the two methods: 0.27 ± 0.09, 0.35 ± 0.06, 0.40 ± 0.04 (standard) versus 0.23 ± 0.05, 0.34 ± 0.03, 0.37 ± 0.02 (accelerated); for anterior, medial, and posterior slices, respectively, whereas the corresponding vertical r gradients were significant (P < 0.001): 0.021 ± 0.007 (standard) versus 0.019 ± 0.005 (accelerated) (cm-1). Conclusion Quadruple phased array coil simulations resulted in an optimal acceleration factor of ∼2× independent of imaging resolution. Results advocate undersampled image acceleration to improve accuracy of fractional ventilation measurement with hyperpolarized gas MRI. Magn Reson Med 70:1353-1359, 2013. © 2013 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1353-1359
Number of pages7
JournalMagnetic resonance in medicine
Volume70
Issue number5
DOIs
StatePublished - Nov 2013

Keywords

  • accelerated ventilation imaging
  • fractional ventilation
  • generalized auto-calibrating partially parallel acquisition
  • hyperpolarized gas MRI
  • mechanical ventilation
  • parallel MRI
  • pulmonary ventilation
  • quantitative lung imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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