Accelerated atherosclerosis and elevated lipoprotein (a) after liver transplantation

Abdulla A. Damluji, Diala El-Maouche, Ali Alsulaimi, Paul Martin, Robert D. Shamburek, Ronald B. Goldberg, Seth J. Baum, Eduardo J. De Marchena

Research output: Contribution to journalArticlepeer-review

Abstract

Cumulative evidence suggests that lipoprotein(a) [Lp(a)] exerts an independent effect on the initiation and progression of atherosclerotic cardiovascular disease. The genetically mediated expression of apolipoprotein(a), which is the key structural and functional component of Lp(a), occurs in hepatocytes with subsequent extracellular Lp(a) assembly at the hepatic cell surface. Here, we describe a case of elevated Lp(a) concentrations identified after (and likely acquired by) orthotopic liver transplantation that contributed to accelerated atherosclerotic cardiovascular disease despite intensive therapeutic interventions. This case study represents an important example to include Lp(a) screening in routine lipid panel testing for all liver transplant donors and recipients; to reduce unanticipated and debilitating cardiovascular morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)434-437
Number of pages4
JournalJournal of clinical lipidology
Volume10
Issue number2
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Lipids
  • Lp(a)
  • Prevention
  • Therapy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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