Accelerated and Blast Phase Myeloproliferative Neoplasms

Tania Jain, Raajit K. Rampal

Research output: Contribution to journalReview articlepeer-review

Abstract

Accelerated and blast phase myeloproliferative neoplasms are advanced stages of the disease with historically a poor prognosis and little improvement in outcomes thus far. The lack of responses to standard treatments likely results from the more aggressive biology reflected by the higher incidence of complex karyotype and high-risk somatic mutations, which are enriched at the time of transformation. Treatment options include induction chemotherapy (7 + 3) as that used on de novo acute myeloid leukemia or hypomethylating agent–based therapy, which has shown similar outcomes. Allogeneic stem cell transplantation remains the only potential for cure.

Original languageEnglish (US)
Pages (from-to)325-335
Number of pages11
JournalHematology/Oncology Clinics of North America
Volume35
Issue number2
DOIs
StatePublished - Apr 2021

Keywords

  • Accelerated phase
  • Acute myeloid leukemia
  • Blast phase
  • Myeloproliferative neoplasm

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Accelerated and Blast Phase Myeloproliferative Neoplasms'. Together they form a unique fingerprint.

Cite this