Ac-SDKP Reverses Inflammation and Fibrosis in Rats with Heart Failure after Myocardial Infarction

Fang Yang, Xiao Ping Yang, Yun He Liu, Jiang Xu, Oscar Cingolani, Nour Eddine Rhaleb, Oscar A. Carretero

Research output: Contribution to journalArticle

Abstract

Inflammation may play an important role in the pathogenesis of cardiac fibrosis in heart failure (HF) after myocardial infarction (MI). N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a naturally occurring antifibrotic peptide whose plasma concentration is increased 4- to 5-fold by angiotensin-converting enzyme inhibitors. We tested the hypothesis that in rats with HF after MI, Ac-SDKP acts as an anti-inflammatory cytokine, preventing and also reversing cardiac fibrosis in the noninfarcted area (reactive fibrosis), and thus affording functional improvement. We found that Ac-SDKP significantly decreased total collagen content in the prevention group from 23.7±0.9 to 15.0±0.7 μg/mg and in the reversal group from 22.6±2.2 to 14.4±1.6 (P2, p2, P2, P2, P

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalHypertension
Volume43
Issue number2 I
DOIs
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Fibrosis
Heart Failure
Myocardial Infarction
Inflammation
Angiotensin-Converting Enzyme Inhibitors
Anti-Inflammatory Agents
Collagen
Cytokines
Peptides
goralatide

Keywords

  • Cardiac function
  • Collagen
  • Macrophages
  • Myocardial infarction
  • Rat
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ac-SDKP Reverses Inflammation and Fibrosis in Rats with Heart Failure after Myocardial Infarction. / Yang, Fang; Yang, Xiao Ping; Liu, Yun He; Xu, Jiang; Cingolani, Oscar; Rhaleb, Nour Eddine; Carretero, Oscar A.

In: Hypertension, Vol. 43, No. 2 I, 02.2004, p. 229-236.

Research output: Contribution to journalArticle

Yang, Fang ; Yang, Xiao Ping ; Liu, Yun He ; Xu, Jiang ; Cingolani, Oscar ; Rhaleb, Nour Eddine ; Carretero, Oscar A. / Ac-SDKP Reverses Inflammation and Fibrosis in Rats with Heart Failure after Myocardial Infarction. In: Hypertension. 2004 ; Vol. 43, No. 2 I. pp. 229-236.
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