CHOLERA exotoxin causes fluid production by the intestine when instilled into jejunal or ileal loops of anaesthetized rabbits1-3. Profuse quantities of isotonic fluid are produced by the small intestine without histological alteration of the mucosa4. The pathogenesis of the increased fluid production by the intestine in cholera is unsettled. It has not been determined whether the fluid production is the result of increased intestinal secretion, decreased intestinal absorption or a combination of these two factors. To assess the importance of altered intestinal absorption, absorption of d-glucose by the rabbit jejunum was measured both in the presence and absence of cholera diarrhoea.
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