Absorption of d-glucose by the rabbit jejunum during cholera toxin-induced diarrhoea

Harold A. Serebro, Theodore M Bayless, Thomas R. Hendrix, Frank L. Iber, Thomas McGonagle

Research output: Contribution to journalArticle

Abstract

CHOLERA exotoxin causes fluid production by the intestine when instilled into jejunal or ileal loops of anaesthetized rabbits1-3. Profuse quantities of isotonic fluid are produced by the small intestine without histological alteration of the mucosa4. The pathogenesis of the increased fluid production by the intestine in cholera is unsettled. It has not been determined whether the fluid production is the result of increased intestinal secretion, decreased intestinal absorption or a combination of these two factors. To assess the importance of altered intestinal absorption, absorption of d-glucose by the rabbit jejunum was measured both in the presence and absence of cholera diarrhoea.

Original languageEnglish (US)
Pages (from-to)1272-1273
Number of pages2
JournalNature
Volume217
Issue number5135
DOIs
StatePublished - 1968

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Cholera
Cholera Toxin
Intestinal Absorption
Jejunum
Intestines
Diarrhea
Intestinal Secretions
Rabbits
Glucose
Exotoxins
Small Intestine

ASJC Scopus subject areas

  • General

Cite this

Serebro, H. A., Bayless, T. M., Hendrix, T. R., Iber, F. L., & McGonagle, T. (1968). Absorption of d-glucose by the rabbit jejunum during cholera toxin-induced diarrhoea. Nature, 217(5135), 1272-1273. https://doi.org/10.1038/2171272a0

Absorption of d-glucose by the rabbit jejunum during cholera toxin-induced diarrhoea. / Serebro, Harold A.; Bayless, Theodore M; Hendrix, Thomas R.; Iber, Frank L.; McGonagle, Thomas.

In: Nature, Vol. 217, No. 5135, 1968, p. 1272-1273.

Research output: Contribution to journalArticle

Serebro, HA, Bayless, TM, Hendrix, TR, Iber, FL & McGonagle, T 1968, 'Absorption of d-glucose by the rabbit jejunum during cholera toxin-induced diarrhoea', Nature, vol. 217, no. 5135, pp. 1272-1273. https://doi.org/10.1038/2171272a0
Serebro, Harold A. ; Bayless, Theodore M ; Hendrix, Thomas R. ; Iber, Frank L. ; McGonagle, Thomas. / Absorption of d-glucose by the rabbit jejunum during cholera toxin-induced diarrhoea. In: Nature. 1968 ; Vol. 217, No. 5135. pp. 1272-1273.
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