Ibuprofen is a nonsteroidal antiinflammatory agent extensively used in the treatment of pain and inflammatory disorders. Most pharmacokinetic studies of ibuprofen have involved healthy young male volunteers. However, patients who use ibuprofen for clinical purposes are often elderly and many are women. Previous studies have documented alterations in drug disposition associated with the aging process. The present study assesses the effects of age and sex and the pharmacokinetics of single doses of ibuprofen in healthy volunteers.
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