Absorption and disposition of ibuprofen in the elderly

D. J. Greenblatt, D. R. Abernethy, R. Matlis, J. S. Harmatz, R. I. Shader

Research output: Contribution to journalArticle

Abstract

Ibuprofen is a nonsteroidal antiinflammatory agent extensively used in the treatment of pain and inflammatory disorders. Most pharmacokinetic studies of ibuprofen have involved healthy young male volunteers. However, patients who use ibuprofen for clinical purposes are often elderly and many are women. Previous studies have documented alterations in drug disposition associated with the aging process. The present study assesses the effects of age and sex and the pharmacokinetics of single doses of ibuprofen in healthy volunteers.

Original languageEnglish (US)
Pages (from-to)1066-1069
Number of pages4
JournalArthritis and Rheumatism
Volume27
Issue number9
DOIs
StatePublished - 1984
Externally publishedYes

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Ibuprofen
Pharmacokinetics
Somatoform Disorders
Non-Steroidal Anti-Inflammatory Agents
Volunteers
Healthy Volunteers
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Greenblatt, D. J., Abernethy, D. R., Matlis, R., Harmatz, J. S., & Shader, R. I. (1984). Absorption and disposition of ibuprofen in the elderly. Arthritis and Rheumatism, 27(9), 1066-1069. https://doi.org/10.1002/art.1780270918

Absorption and disposition of ibuprofen in the elderly. / Greenblatt, D. J.; Abernethy, D. R.; Matlis, R.; Harmatz, J. S.; Shader, R. I.

In: Arthritis and Rheumatism, Vol. 27, No. 9, 1984, p. 1066-1069.

Research output: Contribution to journalArticle

Greenblatt, DJ, Abernethy, DR, Matlis, R, Harmatz, JS & Shader, RI 1984, 'Absorption and disposition of ibuprofen in the elderly', Arthritis and Rheumatism, vol. 27, no. 9, pp. 1066-1069. https://doi.org/10.1002/art.1780270918
Greenblatt DJ, Abernethy DR, Matlis R, Harmatz JS, Shader RI. Absorption and disposition of ibuprofen in the elderly. Arthritis and Rheumatism. 1984;27(9):1066-1069. https://doi.org/10.1002/art.1780270918
Greenblatt, D. J. ; Abernethy, D. R. ; Matlis, R. ; Harmatz, J. S. ; Shader, R. I. / Absorption and disposition of ibuprofen in the elderly. In: Arthritis and Rheumatism. 1984 ; Vol. 27, No. 9. pp. 1066-1069.
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