Absent or Excessive Corpus Luteum Number Is Associated With Altered Maternal Vascular Health in Early Pregnancy

Frauke von Versen-Höynck, Purnima Narasimhan, Elif Seda Selamet Tierney, Nadine Martinez, Kirk P. Conrad, Valerie Baker, Virginia D. Winn

Research output: Contribution to journalArticle

Abstract

Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health. Vascular dysfunction predates clinical presentation of preeclampsia. Therefore, we examined if a nonphysiological hormonal milieu, a modifiable state, affects maternal vascular health in early pregnancy. Blood pressure, endothelial function, circulating endothelial progenitor cell numbers, lipid levels, and corpus luteum (CL) hormones were compared in a prospective cohort of women with infertility history based on number of CL: 0 CL (programmed frozen embryo transfer [FET], N=18); 1 CL (spontaneous conception [N=16] and natural cycle FET [N=12]); or >3 CL associated with in vitro fertilization [N=11]. Women with 0 or >3 CL lacked the drop in mean arterial blood pressure compared with those with 1 CL (both P=0.05). Reactive hyperemia index was impaired in women with 0 CL compared with 1 CL ( P=0.04) while baseline pulse wave amplitude was higher with > 3 CL compared with 1 CL ( P=0.01) or 0 CL ( P=0.01). Comparing only FET cycles, a lower reactive hyperemia index and a higher augmentation index is noted in FETs with suppressed CL compared with FETs in a natural cycle (both P=0.03). The number of angiogenic and nonangiogenic circulating endothelial progenitor cell numbers was lower in the absence of a CL in FETs ( P=0.01 and P=0.03). Vascular health in early pregnancy is altered in women with aberrant numbers of CL (0 or >3) and might represent insufficient cardiovascular adaptation contributing to an increased risk of preeclampsia.

Original languageEnglish (US)
Pages (from-to)680-690
Number of pages11
JournalHypertension (Dallas, Tex. : 1979)
Volume73
Issue number3
DOIs
StatePublished - Mar 1 2019
Externally publishedYes

Fingerprint

Corpus Luteum
Blood Vessels
Pregnancy
Embryo Transfer
Pre-Eclampsia
Hyperemia
Maternal Health
Corpus Luteum Hormones
Arterial Pressure
Cell Count
Fertilization in Vitro
Prednisolone
Infertility
Reproduction

Keywords

  • corpus luteum
  • endothelial progenitor cells
  • infertility
  • pregnancy
  • vascular endothelium

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Absent or Excessive Corpus Luteum Number Is Associated With Altered Maternal Vascular Health in Early Pregnancy. / von Versen-Höynck, Frauke; Narasimhan, Purnima; Selamet Tierney, Elif Seda; Martinez, Nadine; Conrad, Kirk P.; Baker, Valerie; Winn, Virginia D.

In: Hypertension (Dallas, Tex. : 1979), Vol. 73, No. 3, 01.03.2019, p. 680-690.

Research output: Contribution to journalArticle

von Versen-Höynck, Frauke ; Narasimhan, Purnima ; Selamet Tierney, Elif Seda ; Martinez, Nadine ; Conrad, Kirk P. ; Baker, Valerie ; Winn, Virginia D. / Absent or Excessive Corpus Luteum Number Is Associated With Altered Maternal Vascular Health in Early Pregnancy. In: Hypertension (Dallas, Tex. : 1979). 2019 ; Vol. 73, No. 3. pp. 680-690.
@article{6d3b03c898ea4bb0a899aa12f07cf89d,
title = "Absent or Excessive Corpus Luteum Number Is Associated With Altered Maternal Vascular Health in Early Pregnancy",
abstract = "Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health. Vascular dysfunction predates clinical presentation of preeclampsia. Therefore, we examined if a nonphysiological hormonal milieu, a modifiable state, affects maternal vascular health in early pregnancy. Blood pressure, endothelial function, circulating endothelial progenitor cell numbers, lipid levels, and corpus luteum (CL) hormones were compared in a prospective cohort of women with infertility history based on number of CL: 0 CL (programmed frozen embryo transfer [FET], N=18); 1 CL (spontaneous conception [N=16] and natural cycle FET [N=12]); or >3 CL associated with in vitro fertilization [N=11]. Women with 0 or >3 CL lacked the drop in mean arterial blood pressure compared with those with 1 CL (both P=0.05). Reactive hyperemia index was impaired in women with 0 CL compared with 1 CL ( P=0.04) while baseline pulse wave amplitude was higher with > 3 CL compared with 1 CL ( P=0.01) or 0 CL ( P=0.01). Comparing only FET cycles, a lower reactive hyperemia index and a higher augmentation index is noted in FETs with suppressed CL compared with FETs in a natural cycle (both P=0.03). The number of angiogenic and nonangiogenic circulating endothelial progenitor cell numbers was lower in the absence of a CL in FETs ( P=0.01 and P=0.03). Vascular health in early pregnancy is altered in women with aberrant numbers of CL (0 or >3) and might represent insufficient cardiovascular adaptation contributing to an increased risk of preeclampsia.",
keywords = "corpus luteum, endothelial progenitor cells, infertility, pregnancy, vascular endothelium",
author = "{von Versen-H{\"o}ynck}, Frauke and Purnima Narasimhan and {Selamet Tierney}, {Elif Seda} and Nadine Martinez and Conrad, {Kirk P.} and Valerie Baker and Winn, {Virginia D.}",
year = "2019",
month = "3",
day = "1",
doi = "10.1161/HYPERTENSIONAHA.118.12046",
language = "English (US)",
volume = "73",
pages = "680--690",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Absent or Excessive Corpus Luteum Number Is Associated With Altered Maternal Vascular Health in Early Pregnancy

AU - von Versen-Höynck, Frauke

AU - Narasimhan, Purnima

AU - Selamet Tierney, Elif Seda

AU - Martinez, Nadine

AU - Conrad, Kirk P.

AU - Baker, Valerie

AU - Winn, Virginia D.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health. Vascular dysfunction predates clinical presentation of preeclampsia. Therefore, we examined if a nonphysiological hormonal milieu, a modifiable state, affects maternal vascular health in early pregnancy. Blood pressure, endothelial function, circulating endothelial progenitor cell numbers, lipid levels, and corpus luteum (CL) hormones were compared in a prospective cohort of women with infertility history based on number of CL: 0 CL (programmed frozen embryo transfer [FET], N=18); 1 CL (spontaneous conception [N=16] and natural cycle FET [N=12]); or >3 CL associated with in vitro fertilization [N=11]. Women with 0 or >3 CL lacked the drop in mean arterial blood pressure compared with those with 1 CL (both P=0.05). Reactive hyperemia index was impaired in women with 0 CL compared with 1 CL ( P=0.04) while baseline pulse wave amplitude was higher with > 3 CL compared with 1 CL ( P=0.01) or 0 CL ( P=0.01). Comparing only FET cycles, a lower reactive hyperemia index and a higher augmentation index is noted in FETs with suppressed CL compared with FETs in a natural cycle (both P=0.03). The number of angiogenic and nonangiogenic circulating endothelial progenitor cell numbers was lower in the absence of a CL in FETs ( P=0.01 and P=0.03). Vascular health in early pregnancy is altered in women with aberrant numbers of CL (0 or >3) and might represent insufficient cardiovascular adaptation contributing to an increased risk of preeclampsia.

AB - Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health. Vascular dysfunction predates clinical presentation of preeclampsia. Therefore, we examined if a nonphysiological hormonal milieu, a modifiable state, affects maternal vascular health in early pregnancy. Blood pressure, endothelial function, circulating endothelial progenitor cell numbers, lipid levels, and corpus luteum (CL) hormones were compared in a prospective cohort of women with infertility history based on number of CL: 0 CL (programmed frozen embryo transfer [FET], N=18); 1 CL (spontaneous conception [N=16] and natural cycle FET [N=12]); or >3 CL associated with in vitro fertilization [N=11]. Women with 0 or >3 CL lacked the drop in mean arterial blood pressure compared with those with 1 CL (both P=0.05). Reactive hyperemia index was impaired in women with 0 CL compared with 1 CL ( P=0.04) while baseline pulse wave amplitude was higher with > 3 CL compared with 1 CL ( P=0.01) or 0 CL ( P=0.01). Comparing only FET cycles, a lower reactive hyperemia index and a higher augmentation index is noted in FETs with suppressed CL compared with FETs in a natural cycle (both P=0.03). The number of angiogenic and nonangiogenic circulating endothelial progenitor cell numbers was lower in the absence of a CL in FETs ( P=0.01 and P=0.03). Vascular health in early pregnancy is altered in women with aberrant numbers of CL (0 or >3) and might represent insufficient cardiovascular adaptation contributing to an increased risk of preeclampsia.

KW - corpus luteum

KW - endothelial progenitor cells

KW - infertility

KW - pregnancy

KW - vascular endothelium

UR - http://www.scopus.com/inward/record.url?scp=85061514661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061514661&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.118.12046

DO - 10.1161/HYPERTENSIONAHA.118.12046

M3 - Article

VL - 73

SP - 680

EP - 690

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 3

ER -