Absence of Sleep-Related Elevation of Growth Hormone Level in Patients With Stroke

Antonio Culebras, Myron Miller

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


To determine the effect of defined suprahypothalamic lesions on sleep-related growth hormone (GH) secretion, eight patients with hemispheric lesions of vascular origin were studied in a sleep laboratory on two consecutive nights. Despite the normal onset and increased time spent in slow-wave sleep (SWS), the patients failed to show the nocturnal rise in plasma GH concentration that occurred in association with onset of SWS in five age-matched healthy subjects. Arginine hydrochloride infusion in the patients produced a normal GH rise, indicating integrity of the hypothalamic-pituitary axis. Dissociation between SWS and GH secretion in patients with suprahypothalamic damage suggests that cortical-subcortical structures are involved in the integration of SWS with nocturnal GH secretion. There is support for the presence of a thalamic regulatory center responsible for the control of GH release during sleep.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalArchives of neurology
Issue number5
StatePublished - May 1983
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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