TY - JOUR
T1 - Absence of Recoverable Infectious Virus and Unique Immune Responses in an Asymptomatic HIV+ Long-Term Survivor
AU - Schwartz, David
AU - Sharma, Usha
AU - Busch, Michael
AU - Weinhold, Kent
AU - Matthews, Tom
AU - Lieberman, Judy
AU - Birx, Deborah
AU - Farzedagen, Hoomay
AU - Margolick, Joseph
AU - Quinn, Thomas
AU - Davis, Brian
AU - Bagasra, Omar
AU - Pomerantz, Roger
AU - Viscidi, Raphael
PY - 1994/12
Y1 - 1994/12
N2 - We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981. She had no acute febrile syndrome and has never had HIV-associated clinical signs or symptoms in the 13 years since infection. She was first tested and found positive for HIV antibodies in 1985, and the infected blood donor was diagnosed with AIDS in 1986 and died of AIDS-related complications in 1989. Two other recipients of packed erythrocytes from this donor (in 1980 and 1982) also became infected and were subsequently diagnosed with AIDS. Between January 1986 and April 1994, in the setting of continuous and unambiguous Western blot HIV-specific antibodies and intermittently positive low-level HIV DNA signal after polymerase chain reaction (PCR) amplification, more than 30 separate cell cocultures performed in several independent laboratories failed to yield evidence of infectious virus, despite special efforts to induce and detect HIV replication. Immunologically, a strong in vitro proliferative response to HIV envelope proteins also distinguished this subject from other asymptomatic HIV+ individuals.
AB - We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981. She had no acute febrile syndrome and has never had HIV-associated clinical signs or symptoms in the 13 years since infection. She was first tested and found positive for HIV antibodies in 1985, and the infected blood donor was diagnosed with AIDS in 1986 and died of AIDS-related complications in 1989. Two other recipients of packed erythrocytes from this donor (in 1980 and 1982) also became infected and were subsequently diagnosed with AIDS. Between January 1986 and April 1994, in the setting of continuous and unambiguous Western blot HIV-specific antibodies and intermittently positive low-level HIV DNA signal after polymerase chain reaction (PCR) amplification, more than 30 separate cell cocultures performed in several independent laboratories failed to yield evidence of infectious virus, despite special efforts to induce and detect HIV replication. Immunologically, a strong in vitro proliferative response to HIV envelope proteins also distinguished this subject from other asymptomatic HIV+ individuals.
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U2 - 10.1089/aid.1994.10.1703
DO - 10.1089/aid.1994.10.1703
M3 - Article
C2 - 7888230
AN - SCOPUS:0028670688
SN - 0889-2229
VL - 10
SP - 1703
EP - 1711
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 12
ER -