@article{a5eb224730294daeb5f84506fcb7c279,
title = "Absence of normal keratan sulfate in the blood of patients with macular corneal dystrophy",
abstract = "We measured levels of sulfated keratan sulfate in serum using a monoclonal antibody in an enzyme-linked immunosorbent assay. Sulfated keratan sulfate was not detected in the serum of 16 patients with macular corneal dystrophy, but was present at normal levels in 66 patients with other corneal diseases. There were no differences with respect to age, sex, and other ocular findings. This monoclonal antibody recognizes a sulfated carbohydrate epitope present in both corneal and skeletal keratan sulfate. Since most serum keratan sulfate is derived from the cartilages, the defect in keratan sulfate synthesis in macular corneal dystrophy may not be restricted to corneal cells. This assay should prove useful in the diagnosis of macular corneal dystrophy, particularly in children at risk before the appearance of opacification.",
author = "Thonar, {Eugene J.M.A.} and Meyer, {Roger F.} and Dennis, {Richard F.} and Lenz, {Mary Ellen} and Brian Maldonado and Hassell, {John R.} and Hewitt, {A. Tyl} and Stark, {Walter J.} and Stock, {E. Lee} and Kuettner, {Klaus E.} and Klintworth, {Gordon K.}",
note = "Funding Information: From the Departments of Biochemistry (Drs. Thonar and Kuettner, Ms. Lenz, and Mr. Maldonado) and Ophthalmology (Dr. Dennis), Rush-Presbyterian-St. Luke's Medical Center, Chicago; the Department of Ophthalmology, University of Michigan, Ann Arbor (Dr. Meyer); the Laboratory of Developmental Biology and Anomalies, National Institutes of Health, Bethesda, Md (Dr. Hassell); the Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, Baltimore (Drs. Hewitt and Stark); the Department of Ophthalmology, Northwestern University Medical School, Chicago (Dr. Stock); and the Departments of Ophthalmology and Pathology, Duke University Medical Center, Durham (Dr. Klintworth). This study was supported by the William Noble Lane Medical Research Organization and by National Institutes of Health grants AG-04736 (Dr. Thonar) and EY-00146 (Dr. Klintworth).",
year = "1986",
month = nov,
day = "15",
doi = "10.1016/0002-9394(86)90525-8",
language = "English (US)",
volume = "102",
pages = "561--569",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5",
}