Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs

J. B. Jackson; S. Y. Kwok; J. S. Hopsicker; K. J. Sannerud; J. J. Sninsky; J. R. Edson; H. H. Balfour

Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs

J. B. Jackson, S. Y. Kwok, J. S. Hopsicker, K. J. Sannerud, J. J. Sninsky, J. R. Edson, H. H. Balfour

Research output: Contribution to journal › Article › peer-review

Abstract

In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1-infected individuals is probably very low.

Original language	English (US)
Pages (from-to)	265-267
Number of pages	3
Journal	Transfusion
Volume	29
Issue number	3
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Immunology
Hematology

Cite this

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title = "Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs",

abstract = "In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1-infected individuals is probably very low.",

author = "Jackson, {J. B.} and Kwok, {S. Y.} and Hopsicker, {J. S.} and Sannerud, {K. J.} and Sninsky, {J. J.} and Edson, {J. R.} and Balfour, {H. H.}",

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language = "English (US)",

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AU - Jackson, J. B.

AU - Kwok, S. Y.

AU - Hopsicker, J. S.

AU - Sannerud, K. J.

AU - Sninsky, J. J.

AU - Edson, J. R.

AU - Balfour, H. H.

PY - 1989

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AB - In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1-infected individuals is probably very low.

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Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs

Abstract

ASJC Scopus subject areas

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