Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis

Tim Ullrich, Yi Wei Tang, Hernan Correa, Steven A. Garzon, Akhil Maheshwari, Melissa Hill, Pranathi Matta, Mohan K. Krishnan, Jörn Hendrik Weitkamp

Research output: Contribution to journalArticlepeer-review

Abstract

Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in premature infants and has been linked with viral antigens in as much as 40% of cases in single-center cohorts. We examined 28 tissue sections from surgically resected ileum from 27 preterm infants with NEC from 2 separate institutions for 15 common bacterial, viral, and parasitic gastrointestinal pathogens using multiplex reverse transcriptase polymerase chain reaction amplification and suspension array detection methods. We did not detect infectious enteritis pathogens in any of the NEC tissues and conclude that gastrointestinal pathogens are a rare cause of NEC.

Original languageEnglish (US)
Pages (from-to)413-414
Number of pages2
JournalPediatric Infectious Disease Journal
Volume31
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

Keywords

  • intestinal diseases
  • necrotizing enterocolitis
  • reverse transcriptase polymerase chain reaction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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