Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis

Tim Ullrich; Yi Wei Tang; Hernan Correa; Steven A. Garzon; Akhil Maheshwari; Melissa Hill; Pranathi Matta; Mohan K. Krishnan; Jörn Hendrik Weitkamp

doi:10.1097/INF.0b013e318242534a

Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis

Tim Ullrich, Yi Wei Tang, Hernan Correa, Steven A. Garzon, Akhil Maheshwari, Melissa Hill, Pranathi Matta, Mohan K. Krishnan, Jörn Hendrik Weitkamp

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in premature infants and has been linked with viral antigens in as much as 40% of cases in single-center cohorts. We examined 28 tissue sections from surgically resected ileum from 27 preterm infants with NEC from 2 separate institutions for 15 common bacterial, viral, and parasitic gastrointestinal pathogens using multiplex reverse transcriptase polymerase chain reaction amplification and suspension array detection methods. We did not detect infectious enteritis pathogens in any of the NEC tissues and conclude that gastrointestinal pathogens are a rare cause of NEC.

Original language	English (US)
Pages (from-to)	413-414
Number of pages	2
Journal	Pediatric Infectious Disease Journal
Volume	31
Issue number	4
DOIs	https://doi.org/10.1097/INF.0b013e318242534a
State	Published - Apr 2012

Keywords

intestinal diseases
necrotizing enterocolitis
reverse transcriptase polymerase chain reaction

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0b013e318242534a

Cite this

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title = "Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis",

abstract = "Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in premature infants and has been linked with viral antigens in as much as 40% of cases in single-center cohorts. We examined 28 tissue sections from surgically resected ileum from 27 preterm infants with NEC from 2 separate institutions for 15 common bacterial, viral, and parasitic gastrointestinal pathogens using multiplex reverse transcriptase polymerase chain reaction amplification and suspension array detection methods. We did not detect infectious enteritis pathogens in any of the NEC tissues and conclude that gastrointestinal pathogens are a rare cause of NEC.",

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AU - Ullrich, Tim

AU - Tang, Yi Wei

AU - Correa, Hernan

AU - Garzon, Steven A.

AU - Maheshwari, Akhil

AU - Hill, Melissa

AU - Matta, Pranathi

AU - Krishnan, Mohan K.

AU - Weitkamp, Jörn Hendrik

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AB - Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in premature infants and has been linked with viral antigens in as much as 40% of cases in single-center cohorts. We examined 28 tissue sections from surgically resected ileum from 27 preterm infants with NEC from 2 separate institutions for 15 common bacterial, viral, and parasitic gastrointestinal pathogens using multiplex reverse transcriptase polymerase chain reaction amplification and suspension array detection methods. We did not detect infectious enteritis pathogens in any of the NEC tissues and conclude that gastrointestinal pathogens are a rare cause of NEC.

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KW - reverse transcriptase polymerase chain reaction

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Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis

Abstract

Keywords

ASJC Scopus subject areas

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