Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22

Nazneen Rahman; M. Dawn Teare; Sheila Seal; Helene Renard; Jon Mangion; Chantal Cour; Deborah Thompson; Yin Shugart; Diana Eccles; Peter Devilee; Hanne Meijers; Katherine L. Nathanson; Susan L. Neuhausen; Barbara Weber; Jenny Chang-Claude; Douglas F. Easton; David Goldgar; Michael R. Stratton

Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22

Nazneen Rahman, M. Dawn Teare, Sheila Seal, Helene Renard, Jon Mangion, Chantal Cour, Deborah Thompson, Yin Shugart, Diana Eccles, Peter Devilee, Hanne Meijers, Katherine L. Nathanson, Susan L. Neuhausen, Barbara Weber, Jenny Chang-Claude, Douglas F. Easton, David Goldgar, Michael R. Stratton

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Several recent studies indicate that the majority of families with five or fewer cases of breast cancer and no cases of ovarian cancer are not due to BRCA1 or BRCA2. It has been proposed that a further breast cancer susceptibility gene that may account for some of these families is located on chromosome 8p12-p22. We have identified 31 site-specific breast cancer families that have a greater than 80% posterior probability of being due to genes other than BRCA1 or BRCA2. These families have been examined for linkage to 8p12-p22 using markers flanking the putative location of the gene. The overall multi-point LOD score is strongly negative across the whole 44 cM. The individual multi-point LOD score is negative in 23 families and only exceeds 0.5 in a single family (with a multi-point LOD score of 1.22). The maximum heterogeneity LOD score was 0.03 at marker D8S136 with estimated proportion linked (α) of 3% (95% CI 0-30%). These data do not lend support to the hypothesis that chromosome 8p12-p22 harbours a familial breast cancer susceptibility gene.

Original language	English (US)
Pages (from-to)	4170-4173
Number of pages	4
Journal	Oncogene
Volume	19
Issue number	36
State	Published - Aug 24 2000
Externally published	Yes

Keywords

BRCA1
BRCA2
Breast cancer
Chromosome 8p
Familial

ASJC Scopus subject areas

Molecular Biology
Cancer Research
Genetics

Cite this

Rahman, N., Teare, M. D., Seal, S., Renard, H., Mangion, J., Cour, C., Thompson, D., Shugart, Y., Eccles, D., Devilee, P., Meijers, H., Nathanson, K. L., Neuhausen, S. L., Weber, B., Chang-Claude, J., Easton, D. F., Goldgar, D., & Stratton, M. R. (2000). Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22. Oncogene, 19(36), 4170-4173.

@article{2861bab1f17a49629a9d1872027d7cec,

title = "Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22",

abstract = "Several recent studies indicate that the majority of families with five or fewer cases of breast cancer and no cases of ovarian cancer are not due to BRCA1 or BRCA2. It has been proposed that a further breast cancer susceptibility gene that may account for some of these families is located on chromosome 8p12-p22. We have identified 31 site-specific breast cancer families that have a greater than 80% posterior probability of being due to genes other than BRCA1 or BRCA2. These families have been examined for linkage to 8p12-p22 using markers flanking the putative location of the gene. The overall multi-point LOD score is strongly negative across the whole 44 cM. The individual multi-point LOD score is negative in 23 families and only exceeds 0.5 in a single family (with a multi-point LOD score of 1.22). The maximum heterogeneity LOD score was 0.03 at marker D8S136 with estimated proportion linked (α) of 3% (95% CI 0-30%). These data do not lend support to the hypothesis that chromosome 8p12-p22 harbours a familial breast cancer susceptibility gene.",

keywords = "BRCA1, BRCA2, Breast cancer, Chromosome 8p, Familial",

author = "Nazneen Rahman and Teare, {M. Dawn} and Sheila Seal and Helene Renard and Jon Mangion and Chantal Cour and Deborah Thompson and Yin Shugart and Diana Eccles and Peter Devilee and Hanne Meijers and Nathanson, {Katherine L.} and Neuhausen, {Susan L.} and Barbara Weber and Jenny Chang-Claude and Easton, {Douglas F.} and David Goldgar and Stratton, {Michael R.}",

year = "2000",

month = aug,

day = "24",

language = "English (US)",

volume = "19",

pages = "4170--4173",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "36",

}

TY - JOUR

T1 - Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22

AU - Rahman, Nazneen

AU - Teare, M. Dawn

AU - Seal, Sheila

AU - Renard, Helene

AU - Mangion, Jon

AU - Cour, Chantal

AU - Thompson, Deborah

AU - Shugart, Yin

AU - Eccles, Diana

AU - Devilee, Peter

AU - Meijers, Hanne

AU - Nathanson, Katherine L.

AU - Neuhausen, Susan L.

AU - Weber, Barbara

AU - Chang-Claude, Jenny

AU - Easton, Douglas F.

AU - Goldgar, David

AU - Stratton, Michael R.

PY - 2000/8/24

Y1 - 2000/8/24

N2 - Several recent studies indicate that the majority of families with five or fewer cases of breast cancer and no cases of ovarian cancer are not due to BRCA1 or BRCA2. It has been proposed that a further breast cancer susceptibility gene that may account for some of these families is located on chromosome 8p12-p22. We have identified 31 site-specific breast cancer families that have a greater than 80% posterior probability of being due to genes other than BRCA1 or BRCA2. These families have been examined for linkage to 8p12-p22 using markers flanking the putative location of the gene. The overall multi-point LOD score is strongly negative across the whole 44 cM. The individual multi-point LOD score is negative in 23 families and only exceeds 0.5 in a single family (with a multi-point LOD score of 1.22). The maximum heterogeneity LOD score was 0.03 at marker D8S136 with estimated proportion linked (α) of 3% (95% CI 0-30%). These data do not lend support to the hypothesis that chromosome 8p12-p22 harbours a familial breast cancer susceptibility gene.

AB - Several recent studies indicate that the majority of families with five or fewer cases of breast cancer and no cases of ovarian cancer are not due to BRCA1 or BRCA2. It has been proposed that a further breast cancer susceptibility gene that may account for some of these families is located on chromosome 8p12-p22. We have identified 31 site-specific breast cancer families that have a greater than 80% posterior probability of being due to genes other than BRCA1 or BRCA2. These families have been examined for linkage to 8p12-p22 using markers flanking the putative location of the gene. The overall multi-point LOD score is strongly negative across the whole 44 cM. The individual multi-point LOD score is negative in 23 families and only exceeds 0.5 in a single family (with a multi-point LOD score of 1.22). The maximum heterogeneity LOD score was 0.03 at marker D8S136 with estimated proportion linked (α) of 3% (95% CI 0-30%). These data do not lend support to the hypothesis that chromosome 8p12-p22 harbours a familial breast cancer susceptibility gene.

KW - BRCA1

KW - BRCA2

KW - Breast cancer

KW - Chromosome 8p

KW - Familial

UR - http://www.scopus.com/inward/record.url?scp=0034710544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034710544&partnerID=8YFLogxK

M3 - Article

C2 - 10962578

AN - SCOPUS:0034710544

SN - 0950-9232

VL - 19

SP - 4170

EP - 4173

JO - Oncogene

JF - Oncogene

IS - 36

ER -

Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this